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Journal of Nuclear Medicine Vol. 48 No. 9 11A-12A
© 2007 by Society of Nuclear Medicine

This Month in JNM

Reduced role for V/Q scintigraphy: Strashun reviews the evolution of multicenter trials of ventilation/perfusion scanning in acute pulmonary embolism and assesses the comparative merits and diagnostic refinements of multidetector CT imaging.
Page 1405

Quantum dots for molecular imaging: Lee looks at current investigations of this promising nanoparticle technology, including the potential for radiotracer-labeled applications that could advance imaging of key cellular molecules in vitro and in vivo.
Page 1408

Very low probability V/Q criteria: Gottschalk and colleagues ask whether ventilation/perfusion scintigraphy, combined with clinical assessment, can reliably exclude a diagnosis of pulmonary embolism, with important findings for patients in whom contrast CT imaging is contraindicated.
Page 1411

Blood-pool SPECT in ARVD: Mariano-Goulart and colleagues describe a technique using global and local systolic parameters acquired with gated blood-pool SPECT to diagnose and characterize the severity of diffuse or localized arrhythmogenic right ventricular dysplasia.
Page 1416
Figure 1

Coronary calcium score and SPECT MPI: Schepis and colleagues investigate the incremental value of coronary calcium scoring as an adjunct to gated SPECT myocardial perfusion imaging for the assessment of coronary artery disease in an intermediate-risk population.
Page 1424

Scintigraphy in gland transplantation: Zhang and colleagues evaluate the multiple benefits of 99mTc-pertechnetate scintigraphy in microvascular autologous transplantation of the submandibular gland in patients with severe keratoconjunctivitis sicca.
Page 1431
Figure 2

Simplified 18F-FMAU PET imaging: Tehrani and colleagues introduce the concept of tumor retention ratio as an alternative to flux measurements in kinetic studies of this thymidine-analog PET tracer in patients with brain or prostate cancer.
Page 1436

99mTc-octreotide scintigraphy in lung cancer: Wang and colleagues compare the clinical value of 99mTc-octreotide scintigraphy with that of 18F-FDG dual-head coincidence imaging in patients with suspected lung cancer.
Page 1442
Figure 3

PET and treatment response in mesothelioma: Francis and colleagues report on the role of serial 18F-FDG PET in the assessment of chemotherapy response in patients with mesothelioma and on the predictive advantages of PET early in the treatment cycle.
Page 1449
Figure 4

SPM analysis of DAT images: Kas et al. describe a promising statistical parametric mapping approach and customized template for automatic analysis of 123I-FP-CIT SPECT imaging of dopamine transporters, without the need for MR reference images.
Page 1459
Figure 5

Clinical PET in brain tumors: Chen provides an educational overview of imaging techniques in malignant gliomas and metastatic tumors of the brain, with a focus on the utility of PET and various radiotracers in diagnosis, staging, and treatment assessment.
Page 1468
Figure 6

D-cis-FPro and thalamic degeneration: Langen and colleagues explore the cerebral uptake of the amino acid cis-4-18F-fluoro-D-proline in PET imaging of rats with focal cortical infarctions.
Page 1482
Figure 7

Extracerebral reference region for PET: Le Foll and colleagues report on an animal study using an extracerebral reference region to quantify nicotinic acetylcholine receptors using PET, an approach with potential utility when no cerebral reference regions are available.
Page 1492
Figure 8

Imaging HER2 expression: Sampath and colleagues conduct preliminary studies with an imaging agent labeled with 111In, a {gamma}-emitter, and a near-infrared fluorescent dye and discuss the potential for this agent in tracking HER2 overexpression in breast cancer.
Page 1501

In vivo quantum dot imaging: Schipper and colleagues use microPET imaging to evaluate the quantitative biodistribution of commercially available 64Cu-labeled quantum dots in mice.
Page 1511
Figure 9

Targeted radiotherapy with transgenes: Mairs and colleagues describe the development of a transfectant mosaic xenograft model for assessment of combined targeted radionuclide therapy and gene therapy using human telomerase transporters.
Page 1519

Field-testing the microPET F120: Kim and colleagues detail independent performance testing results with this third-generation animal PET scanner designed for rodent imaging.
Page 1527

18F-labeled RGD tetramer: Wu and colleagues report on an 18F-labeled tetrameric RGD peptide for PET imaging of {alpha}vß3 expression in both xenograft and spontaneous tumor models.
Page 1536
Figure 10

Chelator influence on targeting: Mier and colleagues investigate whether coupling a novel peptide to the 111In-labeled chelator DOTA results in improved binding and stability and discuss the implications for the clinical potential of peptide sequences identified by phage-displayed library screening.
Page 1545

Enhancement of transgene expression: Kim and colleagues explore the effect of doxorubicin on transgene expression and evaluate the mechanism of enhanced transgene expression by doxorubicin in transfected human anaplastic thyroid cancer cells.
Page 1553

Targeted EGFR radiotherapy: Bailey and colleagues conduct in vitro studies to determine the effect of epidermal growth factor (EGFR) inhibition by gefitinib on the internalization, nuclear translocation, and cytotoxicity of a 111In-DTPA–labeled tracer that targets EGFR-positive cancer cells.
Page 1562


ON THE COVER

Molecular imaging agents dual-labeled with nuclear and optical reporters provide unique opportunities for noninvasive diagnostic imaging with {gamma}-tracers and for subsequent intraoperative guidance with near-infrared fluorophores. These images were obtained after administration of such an agent. The fluorescent signal intensities are significantly higher in tumor regions than elsewhere, demonstrating the molecular specificity of the agent.
Figure 11

See page 1505.

 


Related articles in JNM:

A Reduced Role of V/Q Scintigraphy in the Diagnosis of Acute Pulmonary Embolism
Arnold M. Strashun
JNM 2007 48: 1405-1407. [Full Text]  

Quantum Dots: A Quantum Jump for Molecular Imaging?
Kyung-Han Lee
JNM 2007 48: 1408-1410. [Full Text]  

Very Low Probability Interpretation of V/Q Lung Scans in Combination with Low Probability Objective Clinical Assessment Reliably Excludes Pulmonary Embolism: Data from PIOPED II
Alexander Gottschalk, Paul D. Stein, H. Dirk Sostman, Fadi Matta, and Afzal Beemath
JNM 2007 48: 1411-1415. [Abstract] [Full Text]  

Diagnosis of Diffuse and Localized Arrhythmogenic Right Ventricular Dysplasia by Gated Blood-Pool SPECT
Denis Mariano-Goulart, Laurent Déchaux, François Rouzet, Eric Barbotte, Charles Caderas de Kerleau, Michel Rossi, and Dominique Le Guludec
JNM 2007 48: 1416-1423. [Abstract] [Full Text]  

Added Value of Coronary Artery Calcium Score as an Adjunct to Gated SPECT for the Evaluation of Coronary Artery Disease in an Intermediate-Risk Population
Tiziano Schepis, Oliver Gaemperli, Pascal Koepfli, Mehdi Namdar, Ines Valenta, Hans Scheffel, Sebastian Leschka, Lars Husmann, Franz R. Eberli, Thomas F. Luscher, Hatem Alkadhi, and Philipp A. Kaufmann
JNM 2007 48: 1424-1430. [Abstract] [Full Text]  

Application of 99mTc-Pertechnetate Scintigraphy to Microvascular Autologous Transplantation of the Submandibular Gland in Patients with Severe Keratoconjunctivitis Sicca
Lei Zhang, Zheng-Hong Zhu, Hao-Jie Dai, Zhi-Gang Cai, Chi Mao, Xin Peng, and Guang-Yan Yu
JNM 2007 48: 1431-1435. [Abstract] [Full Text]  

Tumor Imaging Using 1-(2'-deoxy-2'-18F- Fluoro-ß-D-Arabinofuranosyl)Thymine and PET
Omid S. Tehrani, Otto Muzik, Lance K. Heilbrun, Kirk A. Douglas, Jawana M. Lawhorn-Crews, Haihao Sun, Thomas J. Mangner, and Anthony F. Shields
JNM 2007 48: 1436-1441. [Abstract] [Full Text]  

Role of 99mTc-Octreotide Acetate Scintigraphy in Suspected Lung Cancer Compared with 18F-FDG Dual-Head Coincidence Imaging
Feng Wang, Zizheng Wang, Weixuan Yao, Hong Xie, Jie Xu, and Li Tian
JNM 2007 48: 1442-1448. [Abstract] [Full Text]  

Early Prediction of Response to Chemotherapy and Survival in Malignant Pleural Mesothelioma Using a Novel Semiautomated 3-Dimensional Volume-Based Analysis of Serial 18F-FDG PET Scans
Roslyn J. Francis, Michael J. Byrne, Agatha A. van der Schaaf, Jan A. Boucek, Anna K. Nowak, Michael Phillips, Richard Price, Andrew P. Patrikeos, A. William Musk, and Michael J. Millward
JNM 2007 48: 1449-1458. [Abstract] [Full Text]  

Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images
Aurélie Kas, Pierre Payoux, Marie-Odile Habert, Zoulikha Malek, Yann Cointepas, Georges El Fakhri, Philippe Chaumet-Riffaud, Emmanuel Itti, and Philippe Remy
JNM 2007 48: 1459-1467. [Abstract] [Full Text]  

Clinical Applications of PET in Brain Tumors
Wei Chen
JNM 2007 48: 1468-1481. [Abstract] [Full Text]  

Detection of Secondary Thalamic Degeneration After Cortical Infarction Using cis-4-18F-Fluoro- D-Proline
Karl-Josef Langen, Dagmar Salber, Kurt Hamacher, Gabriele Stoffels, Guido Reifenberger, Dirk Pauleit, Heinz H. Coenen, and Karl Zilles
JNM 2007 48: 1482-1491. [Abstract] [Full Text]  

Validation of an Extracerebral Reference Region Approach for the Quantification of Brain Nicotinic Acetylcholine Receptors in Squirrel Monkeys with PET and 2-18F-Fluoro-A-85380
Bernard Le Foll, Svetlana I. Chefer, Alane S. Kimes, Dean Shumway, Steven R. Goldberg, Elliot A. Stein, and Alexey G. Mukhin
JNM 2007 48: 1492-1500. [Abstract] [Full Text]  

Dual-Labeled Trastuzumab-Based Imaging Agent for the Detection of Human Epidermal Growth Factor Receptor 2 Overexpression in Breast Cancer
Lakshmi Sampath, Sunkuk Kwon, Shi Ke, Wei Wang, Rachel Schiff, Michel E. Mawad, and Eva M. Sevick-Muraca
JNM 2007 48: 1501-1510. [Abstract] [Full Text]  

microPET-Based Biodistribution of Quantum Dots in Living Mice
Meike L. Schipper, Zhen Cheng, Sheen-Woo Lee, Laurent A. Bentolila, Gopal Iyer, Jianghong Rao, Xiaoyuan Chen, Anna M. Wu, Shimon Weiss, and Sanjiv S. Gambhir
JNM 2007 48: 1511-1518. [Abstract] [Full Text]  

A Transfectant Mosaic Xenograft Model for Evaluation of Targeted Radiotherapy in Combination with Gene Therapy In Vivo
Robert J. Mairs, Susan C. Ross, Anthony G. McCluskey, and Marie Boyd
JNM 2007 48: 1519-1526. [Abstract] [Full Text]  

Performance Measurement of the microPET Focus 120 Scanner
Jin Su Kim, Jae Sung Lee, Ki Chun Im, Su Jin Kim, Seog-Young Kim, Dong Soo Lee, and Dae Hyuk Moon
JNM 2007 48: 1527-1535. [Abstract] [Full Text]  

microPET of Tumor Integrin {alpha}vß3 Expression Using 18F-Labeled PEGylated Tetrameric RGD Peptide (18F-FPRGD4)
Zhanhong Wu, Zi-Bo Li, Kai Chen, Weibo Cai, Lina He, Frederick T. Chin, Fang Li, and Xiaoyuan Chen
JNM 2007 48: 1536-1544. [Abstract] [Full Text]  

Influence of Chelate Conjugation on a Newly Identified Tumor-Targeting Peptide
Walter Mier, Sabine Zitzmann, Susanne Krämer, Jennifer Reed, Eva-Maria Knapp, Annette Altmann, Michael Eisenhut, and Uwe Haberkorn
JNM 2007 48: 1545-1552. [Abstract] [Full Text]  

Doxorubicin Enhances the Expression of Transgene Under Control of the CMV Promoter in Anaplastic Thyroid Carcinoma Cells
Kwang Il Kim, Joo Hyun Kang, June-Key Chung, Yong Jin Lee, Jae Min Jeong, Dong Soo Lee, and Myung Chul Lee
JNM 2007 48: 1553-1561. [Abstract] [Full Text]  

Epidermal Growth Factor Receptor Inhibition Modulates the Nuclear Localization and Cytotoxicity of the Auger Electron–Emitting Radiopharmaceutical 111In-DTPA–Human Epidermal Growth Factor
Kristy E. Bailey, Danny L. Costantini, Zhongli Cai, Deborah A. Scollard, Zhuo Chen, Raymond M. Reilly, and Katherine A. Vallis
JNM 2007 48: 1562-1570. [Abstract] [Full Text]  




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