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FIGURE 5. Evaluation with z score mapping system of therapeutic effects of donepezil on brain perfusion SPECT for 68-y-old woman. (A) Baseline study 1 mo before donepezil showed significant decrease in rCBF within specific VOI for early AD. Mini-Mental State Examination (MMSE) score was 5 (out of 30). (B) At 3 mo after start of donepezil administration, all rCBF indices decreased from values at initial study, indicating amelioration of rCBF within specific VOI. MMSE score increased to 14 (out of 30).
