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Journal of Nuclear Medicine Vol. 48 No. 8 11a-12a
© 2007 by Society of Nuclear Medicine

This Month in JNM

SPECT vs. PET in graft infection: Burroni and colleagues review the gold standard of scintigraphy with radiolabeled white blood cells in vascular graft infection and the relative merits of PET and PET/CT in this indication.
Page 1227

PET/CT in vascular graft infection: Keidar and colleagues assess the effectiveness of 18F-FDG PET/CT in the diagnosis of vascular graft–related complications and in differentiation between graft and soft-tissue infection.
Page 1230
Figure 1

PET/CT in salivary cancer: Jeong and colleagues compare the prognostic and treatment-planning abilities of 18F-FDG PET/CT and contrast-enhanced CT in patients with high-grade salivary gland malignancies.
Page 1237
Figure 2

Figure 3

Novel PET tracer for GIST: Dimitrakopoulou-Strauss and colleagues describe PET studies with a 68Ga-bombesin analog and 18F-FDG in patients with gastrointestinal stromal tumors to investigate the effects of complementary receptor scintigraphy on diagnostic accuracy.
Page 1245

PET/CT in recurrent esophageal cancer: Guo and colleagues report on the diagnostic and prognostic roles of 18F-FDG PET/CT in patients with suspected recurrence of esophageal squamous cell carcinoma after definitive treatment.
Page 1251

Algorithms not interchangeable: Chen and colleagues provide data on the selection of reconstruction algorithms for 13N-NH3 PET estimation of quantitative myocardial blood flow.
Page 1259
Figure 4

Receptor effect in breast cancer PET: Mavi and colleagues investigate correlations between 18F-FDG uptake of primary breast cancer lesions and predictive and prognostic factors such as C-erbB-2, estrogen, and progesterone receptor states.
Page 1266

SPECT and rCBF in depression treatment: Kohn and colleagues use 99mTc-HMPAO SPECT to determine whether reversal of compromised regional cerebral blood flow in patients with major depressive disorder is dependant on the mode of antidepressant treatment.
Page 1273
Figure 5

18F-MPPF PET for longitudinal studies: Costes and colleagues assess the reliability and reproducibility of binding parameter quantification for this radiolabeled 5-HT1A receptor antagonist through a test–retest study over a long-term period.
Page 1279

Advances in Alzheimer's assessment: Matsuda provides an educational overview of the role of neuroimaging in Alzheimer's disease, with a special focus on the utility of statistical analyses in brain perfusion SPECT, PET, and MRI techniques.
Page 1289
Figure 6

Monitoring myocardial therapy: Taki and colleagues evaluate 99mTc-annexin-V uptake in a rat model of ischemia and reperfusion to determine whether postconditioning or ischemic preconditioning suppress myocardial cell damage or apoptosis.
Page 1301

18F-FDG and mitochondrial membrane potential: Smith and Blaylock report on in vitro research in breast tumor cells to determine how the loss of mitochondrial membrane potential in apoptosis influences 18F-FDG incorporation.
Page 1308

VEGF tumor imaging: Nagengast and colleagues describe the development of a radiolabeled humanized monoclonal antibody for noninvasive in vivo vascular endothelial growth factor visualization and quantification with 111In and 89Zr PET.
Page 1313
Figure 7

Lowered {sigma}1 binding after therapy: van Waarde and colleagues compare early changes in 11C-SA4503 binding and 18F-FDG uptake in gliomas after chemotherapy to evaluate the potential of a radiolabeled {sigma}1-ligand for response monitoring.
Page 1320
Figure 8

64Cu-bombesin analogs for preclinical PET/CT: Garrison and colleagues report on studies in a mouse model of prostate cancer to determine whether the CB-TE2A chelation system could significantly improve the in vivo stability of 64Cu-bombesin analogs.
Page 1327
Figure 9

Novel carrier modules in lymphoma: DeNardo and colleagues characterize the pharmacokinetics of selective high-affinity ligand molecules that show promise as effective radioisotope carriers for molecular-based imaging and treatment of lymphoma.
Page 1338
Figure 10

Imaging of melanoma metastases: Pham and colleagues describe mouse studies with a novel 123I-labeled molecule for SPECT imaging and staging of metastatic dissemination of melanoma tumors and the potential for therapeutic applications.
Page 1348
Figure 11

111In-trastuzumab and nuclear targeting: Costantini and colleagues evaluate the cytotoxicity and tumor-targeting properties of the monoclonal antibody trastuzumab modified with peptides harboring nuclear localization sequences and discuss the potential for radioimmunotherapeutic applications.
Page 1357
Figure 12

Whole-body parametric imaging: Gleisner and colleagues detail a method for pharmacokinetic modeling of distributions of 111In-labeled monoclonal antibodies on individual pixels of planar scintillation camera images.
Page 1369
Figure 13

Solid-phase 99mTc preloading: Misra and colleagues introduce a multimeric, small-molecule radiotracer with high affinity to prostate-specific membrane antigen and describe its production through a solid-phase conversion of sodium 99mTc-pertechnetate to a general-purpose, reactive form.
Page 1379

Chelate stability and 64Cu: Eiblmaier and colleagues explore the question of whether 64Cu localization to cell nuclei from internalizing, receptor-targeted radiopharmaceuticals is related to chelate stability.
Page 1390

Journal impact factors: Currie and Wheat provide a general description of journal impact factor statistics in peer-reviewed nuclear medicine literature and discuss the implications, advantages, and shortcomings of these increasingly referenced metrics.
Page 1397


ON THE COVER

68Ga-BZH3 may be helpful diagnostically in some patients with gastrointestinal stromal tumor. Here, 18F-FDG shows hyper metabolic areas in the liver and stomach, CT shows hypodensity in the same areas, bombesin shows enhancement clearly in the liver but slightly in the stomach, and 18F-FDG–bombesin fusion shows agreement between the tracers in the liver but not in the stomach. Histology revealed stomach tumor and liver metastasis.
Figure 14

See page 1248.

 


Related articles in JNM:

Diagnosis of Vascular Prosthesis Infection: PET or SPECT?
Luca Burroni, Calogero D'Alessandria, and Alberto Signore
JNM 2007 48: 1227-1229. [Full Text]  

Prosthetic Vascular Graft Infection: The Role of 18F-FDG PET/CT
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JNM 2007 48: 1230-1236. [Abstract] [Full Text]  

Role of 18F-FDG PET/CT in Management of High-Grade Salivary Gland Malignancies
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68Ga-Labeled Bombesin Studies in Patients with Gastrointestinal Stromal Tumors: Comparison with 18F-FDG
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Diagnostic and Prognostic Value of 18F-FDG PET/CT for Patients with Suspected Recurrence from Squamous Cell Carcinoma of the Esophagus
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The Effects of Estrogen, Progesterone, and C-erbB-2 Receptor States on 18F-FDG Uptake of Primary Breast Cancer Lesions
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99mTc-HMPAO SPECT Study of Cerebral Perfusion After Treatment with Medication and Electroconvulsive Therapy in Major Depression
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Test–Retest Reproducibility of 18F-MPPF PET in Healthy Humans: A Reliability Study
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Role of Neuroimaging in Alzheimer's Disease, with Emphasis on Brain Perfusion SPECT
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Effect of Postconditioning on Myocardial 99mTc-Annexin-V Uptake: Comparison with Ischemic Preconditioning and Caspase Inhibitor Treatment
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Treatment of Breast Tumor Cells In Vitro with the Mitochondrial Membrane Potential Dissipater Valinomycin Increases 18F-FDG Incorporation
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