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Journal of Nuclear Medicine Vol. 48 No. 7 11a-12a
© 2007 by Society of Nuclear Medicine

This Month in JNM

Nuclear medicine nanotechnology: Reilly reviews the development of carbon nanotubes and looks at the benefits and risks associated with initial in vivo applications in tumor targeting and drug delivery.
Page 1039
Figure 1

Looking for stunning: Silberstein compares outcomes of ablative radioiodine therapy after diagnostic studies with 123I or 131I to determine whether diagnostic dosages reduce the efficacy of postthyroidectomy remnant ablation.
Page 1043

Heterogeneity of low-grade gliomas: Wyss and colleagues use 18F-FET PET in low-grade gliomas to assess cerebral blood flow and microvessel density characteristics, essential elements in understanding and developing advanced chemotherapeutic approaches.
Page 1047
Figure 2

PET/CT in Crohn's disease: Louis and colleagues investigate the efficacy of combined functional/anatomic imaging in the noninvasive localization and characterization of gastrointestinal tract lesions in patients with Crohn's disease.
Page 1053
Figure 3

Error correction in cardiac PET/CT: Büther and colleagues evaluate 2 methods of thresholding CT data to correct for contrast media–related artifacts that impair PET quantification of tracer uptake in cardiac PET/CT imaging.
Page 1060
Figure 4

PET MPI in cardiac disease management: Merhige and colleagues detail the costs and clinical outcomes, including revascularization rates, in groups of patients undergoing 82Rb PET myocardial perfusion imaging (MPI) and SPECT MPI for coronary artery disease.
Page 1069
Figure 5

Brown fat in pheochromocytomas: Hadi and colleagues review 18F-fluorodopamine and 18F-FDG PET/CT images in patients with known or suspected pheochromocytomas to determine whether typical patterns of localized uptake associated with brown adipose fat can be identified.
Page 1077
Figure 6

SPECT/CT parathyroid scintigraphy: Lavely and colleagues compare SPECT/CT, SPECT, and planar imaging in patients with primary hyperparathyroidism and investigate whether localization is improved by dual-phase acquisition in these 3 modalities.
Page 1084

Registration strategies in cardiac SPECT/CT: Goetze and colleagues focus on the role of misregistration in SPECT/CT in a database of more than 100 patients undergoing myocardial perfusion imaging and assess the performance of a software-based approach for reregistration.
Page 1090

Early outcomes after CABG: Wu and colleagues compare the abilities of contrast-enhanced MRI and 18F-FDG PET/201Tl SPECT to assess myocardial viability and predict early functional outcome in patients undergoing coronary artery bypass graft surgery.
Page 1096
Figure 7

Predicting CRT response: Henneman and colleagues investigate whether the degree of left ventricular dyssynchrony as assessed by gated myocardial perfusion SPECT can predict which patients with severe heart failure will respond to cardiac resynchronization therapy.
Page 1104

Cardiac PET/CT artifacts: Gould and colleagues report on causes, results, and corrective approaches in misregistration of helical CT attenuation and emission PET images in patients undergoing PET/CT myocardial perfusion imaging.
Page 1112

82Rb PET/CT myocardial database: Santana and colleagues describe the development and validation of a normal database and criteria for abnormality for rest–stress 82Rb PET/CT myocardial perfusion imaging and highlight the research potential of such a resource.
Page 1122

Normative early AD references: Mosconi and colleagues explore the utility of an 18F-FDG PET database of longitudinally confirmed healthy elderly individuals in improving the diagnosis of Alzheimer's disease and mild cognitive impairment.
Page 1129
Figure 8

Viability in heart failure: Schinkel and colleagues provide an educational overview of current noninvasive techniques for assessing myocardial viability in patients with chronic ischemic left ventricular dysfunction.
Page 1135

Modulation of brain function in Parkinson's: Pellegrino and colleagues describe the PET imaging profile and expression of dopaminergic and metabotropic glutamate receptors in a parkinsonian rodent model, with resulting data that offer insights into the mechanisms of neurodegeneration.
Page 1147

Better brain imaging: Ryu and colleagues use 18F-FCWAY, a PET radioligand for imaging serotonin receptor imaging, to test the ability of disulfiram to inhibit defluorination in humans.
Page 1154

Targeting tumor angiogenesis: Li and colleagues report on the development of and initial studies with 64Cu-labeled multimeric RGD peptides for PET imaging of tumor integrin {alpha}vß3 expression.
Page 1162
Figure 9

Angiogenesis imaging: Rossin and colleagues describe the use of a 76Br-labeled fibronectin-binding human antibody derivative and small-animal PET to image the extra domain B of fibronectin, an angiogenesis-related target in solid tumors.
Page 1172
Figure 10

Tumor targeting with carbon nanotubes: McDevitt and colleagues detail the synthesis and in vitro and in vivo evaluation of novel prototype nanostructures consisting of biologics, radionuclides, fluorochromes, and carbon nanotubes as molecular-level drug delivery platforms.
Page 1180

Radiolytic effects of 211At: Pozzi and Zalutsky offer the third in a series on targeted radiopharmaceutical chemistry, focusing on the effect of radiation dose before initiation of labeling and the potential results on the efficiency of {alpha}-emitter radiopharmaceutical synthesis.
Page 1190

Microvolumetric blood counter: Convert and colleagues describe the development and evaluation of an automated ß-particle blood counter designed to circumvent the limitations of manual sampling in small-animal PET imaging by measuring blood activity in real time.
Page 1197
Figure 11

Imaging glutamate receptors: Treyer and colleagues evaluate different methods for analysis of human data acquired using 11C-ABP688, a novel PET ligand that targets the subtype 5 metabotropic glutamate receptor.
Page 1207

Assessing peripheral arterial occlusive disease: Peñuelas and colleagues investigate the utility of 13N-ammonia small-animal PET imaging for semiquantitative evaluation of hindlimb perfusion in mouse models of acute hindlimb ischemia.
Page 1216
Figure 12


ON THE COVER

Cardiac PET/CT is rapidly expanding despite false-positive results due to misregistration. Averaged cine data acquired during normal breathing can be applied using reconstruction software or visual shifting to eliminate artifactual defects. Properly coregistered PET/CT data provide perfusion images suitable for assessing coronary artery disease.
Figure 13

See page 1117.

 


Related articles in JNM:

Carbon Nanotubes: Potential Benefits and Risks of Nanotechnology in Nuclear Medicine
Raymond M. Reilly
JNM 2007 48: 1039-1042. [Full Text]  

Comparison of Outcomes After 123I Versus 131I Preablation Imaging Before Radioiodine Ablation in Differentiated Thyroid Carcinoma
Edward B. Silberstein
JNM 2007 48: 1043-1046. [Abstract] [Full Text]  

Spatial Heterogeneity of Low-Grade Gliomas at the Capillary Level: A PET Study on Tumor Blood Flow and Amino Acid Uptake
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Noninvasive Assessment of Crohn's Disease Intestinal Lesions with 18F-FDG PET/CT
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JNM 2007 48: 1053-1059. [Abstract] [Full Text]  

Effective Methods to Correct Contrast Agent–Induced Errors in PET Quantification in Cardiac PET/CT
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Impact of Myocardial Perfusion Imaging with PET and 82Rb on Downstream Invasive Procedure Utilization, Costs, and Outcomes in Coronary Disease Management
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Brown Fat Imaging with 18F-6-Fluorodopamine PET/CT, 18F-FDG PET/CT, and 123I-MIBG SPECT: A Study of Patients Being Evaluated for Pheochromocytoma
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Comparison of SPECT/CT, SPECT, and Planar Imaging with Single- and Dual-Phase 99mTc-Sestamibi Parathyroid Scintigraphy
William C. Lavely, Sibyll Goetze, Kent P. Friedman, Jeffrey P. Leal, Zhe Zhang, Elizabeth Garret-Mayer, Alan P. Dackiw, Ralph P. Tufano, Martha A. Zeiger, and Harvey A. Ziessman
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Comparison of Contrast-Enhanced MRI with 18F-FDG PET/201Tl SPECT in Dysfunctional Myocardium: Relation to Early Functional Outcome After Surgical Revascularization in Chronic Ischemic Heart Disease
Yen-Wen Wu, Eiji Tadamura, Masaki Yamamuro, Shotaro Kanao, Akira Marui, Keiichi Tanabara, Masashi Komeda, and Kaori Togashi
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Can LV Dyssynchrony as Assessed with Phase Analysis on Gated Myocardial Perfusion SPECT Predict Response to CRT?
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Frequent Diagnostic Errors in Cardiac PET/CT Due to Misregistration of CT Attenuation and Emission PET Images: A Definitive Analysis of Causes, Consequences, and Corrections
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JNM 2007 48: 1112-1121. [Abstract] [Full Text]  

Quantitative 82Rb PET/CT: Development and Validation of Myocardial Perfusion Database
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Modulation of Dopaminergic and Glutamatergic Brain Function: PET Studies on Parkinsonian Rats
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Disulfiram Inhibits Defluorination of 18F-FCWAY, Reduces Bone Radioactivity, and Enhances Visualization of Radioligand Binding to Serotonin 5-HT1A Receptors in Human Brain
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64Cu-Labeled Tetrameric and Octameric RGD Peptides for Small-Animal PET of Tumor {alpha}vß3 Integrin Expression
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13N-Ammonia PET as a Measurement of Hindlimb Perfusion in a Mouse Model of Peripheral Artery Occlusive Disease
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