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FIGURE 1. Heterogeneity of 18F-FET uptake and CBF in 3 low-grade gliomas. Corresponding axial slices are presented. Color scale represents T/Cb ratio of 18F-FET and CBF. (A) Oligoastrocytoma shows markedly increased 18F-FET uptake and CBF in right frontoinsular region (patient 11 in Table 1). 18F-FET and CBF peak uptake regions coincide; however, active volume of CBF is smaller than active 18F-FET volume. (B) Reduced 18F-FET uptake and CBF in fibrillary astrocytoma (patient 1). (C) Oligoastrocytoma (patient 12). Anterior tumor part involves corpus callosum and shows substantially reduced CBF and 18F-FET uptake when compared with posterior tumor part. This heterogeneity is not evident from any MRI sequences. Yellow line through posterior part of brain and tumor illustrates positioning of trace ROI (Fig. 4).
