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FIGURE 6. Biodistribution of FROP-1 in female BALB/c nu/nu mice carrying FRO82-2 tumors (n = 3 animals per time point) (A) or MCF-7 tumors (n = 6 animals per time point) (B). Animals received intravenous injection of 131I-FROP-1, and radioactivity was measured in tumor and control organs after 5, 15, 45, and 135 min. SEM is shown. (C) Tumor-to-muscle ratios calculated for FRO82-2 and MCF-7 tumors at various time points. (D) Biodistribution of 125I-FROP-1 at 45 min comparing FRO82-2 and MCF-7 tumors incubated with and without Matrigel (BD Biosciences) (n = 3 animals per time point).
