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FIGURE 4. PET images of 11C-(R)-PK11195 uptake in brain in first 10 min of scan (frame 1) and in last 10 min of scan (frame 6) on day 1 of life. Red circle indicates ROI involving whole brain that was drawn to measure uptake in that region. Red arrows indicate region of interventricular zone at level of hippocampus and dentate gyrus. Activity in brain decreases over time for saline-injected control kits, whereas it increases over time for newborn rabbit kits exposed to endotoxin in utero, indicating specific binding of tracer to activated microglial cells in endotoxin-exposed kits. Image intensity is adjusted for dose injected and weight of animal and the SUV scale provided.
