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FIGURE 11. Calculation of transfer coefficients for 2 compartments (tumor [t] and background [b]). Image of each binary compartment as seen by imaging system is obtained by modeling imaging system response. Resulting image is nonbinary image from which 4 transfer coefficients can be calculated. For example, Wtt corresponds to fraction of signal emanating from tumor and detected in tumor, whereas Wtb corresponds to fraction of signal emanating from tumor and detected in background.
