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Journal of Nuclear Medicine Vol. 48 No. 6 11a-12a
© 2007 by Society of Nuclear Medicine

This Month in JNM

Guiding cancer therapy: Rajendran and Mankoff comment on the promise of noninvasive molecular imaging methods, including a tumor hypoxia approach featured in this month's JNM, for characterizing biologic processes within individual patients and thereby enhancing clinical decision making.
Page 855

Automating Parkinson's analysis: Zubal and colleagues describe a fully automated striatal analysis program applied to dopamine transporter images in patients with early symptoms of suspected parkinsonism and compare its performance with that of a trained image-processing technologist.
Page 857

123I-SAP retention in amyloidosis: Hazenberg and colleagues assess the diagnostic performance and prognostic value of a simple parameter describing extravascular 123I-SAP retention in systemic amyloidosis.
Page 865

Imaging and thrombus age: Brighton and colleagues report on the ability of 99mTc-recombinant tissue plasminogen activator imaging to differentiate recent thrombus formation from older thrombi in patients with deep vein thrombosis.
Page 873
Figure 1

Optimal treatment in pediatric thyroid cancer: Handkiewicz-Junak and colleagues detail the results of a retrospective study investigating combinations of treatments associated with decreased risk of locoregional recurrence in children with differentiated thyroid cancer.
Page 879

PET and scintigraphy in bone metastases: Ito and colleagues compare the effectiveness of whole-body 18F-FDG PET and 99mTc bone scintigraphy in detecting metastases in patients with differentiated thyroid cancer after thyroidectomy and before 131I therapy.
Page 889
Figure 2

Diffuse thyroid 18F-FDG uptake: Karantanis and colleagues explore the clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland as an incidental finding on PET/CT.
Page 896
Figure 3

Dual-tracer PET/CT in liver cancer: Ho and colleagues describe the complementary roles of 11C-acetate and 18F-FDG tracers in the PET component of PET/CT detection of metastatic hepatocellular carcinoma.
Page 902

PET/CT registration in liver imaging: Vogel and colleagues evaluate the effect of breathing motion differences on registration accuracy in PET and CT imaging of the liver and offer recommendations on scanner requirements, breath-hold protocols, and reporting.
Page 910
Figure 4Figure 4

Granulocyte CSF, 18F-FDG, and SUVs: Doot and colleagues determine whether chemotherapy and treatment with granulocyte colony–stimulating factor change blood clearance curves and, therefore, affect the relationship between 18F-FDG metabolic rates and standard uptake values.
Page 920
Figure 5

Optimal metabolite curve fitting: Wu and colleagues assess the adequacy of "fit" of 4 metabolite models for correction of arterial input function using data from individuals imaged with 11C-WAY 100635 PET.
Page 926

Partial-volume effect in PET: Soret and colleagues provide an educational overview of the partial-volume effect and its consequences in PET tumor imaging, along with correction models and suggested actions to reduce potential error.
Page 932
Figure 6

PET imaging of perinatal inflammation: Kannan and colleagues explore small-animal 11C-labeled tracer PET imaging of microglial activation as an indicator of inflammation and perinatal brain injury.
Page 946
Figure 7

PET and myocardial glucose metabolism: Herrero and colleagues investigate whether compartmental modeling of 1-11C-glucose PET kinetics can be used for noninvasive measurement of myocardial glucose metabolism beyond its initial extraction.
Page 955

Novel tumor-binding peptide: Zitzmann and colleagues describe the binding properties and pharmacokinetic behavior of a new radiolabeled peptide in both in vitro and in vivo models of follicular thyroid carcinoma.
Page 965

PET in hypoxia-directed radiochemotherapy: Beck and colleagues report on the ability of small-animal PET using the hypoxia tracer 18F-FAZA to predict the success of radiotherapy in combination with tirapazamine, a specific cytotoxin for hypoxic cells.
Page 973

Nicotine and brown adipose tissue uptake: Baba and colleagues evaluate the effects of ß-adrenergic agonists on 18F-FDG uptake in brown adipose tissue in rats and offer cautions about the effects of nicotine on PET imaging.
Page 981

PET melanocortin receptor expression imaging: Cheng and colleagues investigate 18F-FB-NAPamide as a promising molecular probe for {alpha}-melanocyte-stimulating hormone receptor–positive melanoma and describe initial studies in mice.
Page 987
Figure 8

Antibody penetration in tumor tissue: Thurber and colleagues address the complexities of and kinetic barriers to tumor targeting in antibody-based therapeutics with a theoretical model that suggests that such therapies may be better suited to micrometastases than vascularized tumors.
Page 995
Figure 9

DNA nanoirradiation and cell kill: Reske and colleagues investigate whether selective nanoirradiation of DNA with Auger electrons emitted by 123I-ITdU can induce apoptosis and break resistance to doxorubicin, ß-, and {gamma}-irradiation in leukemia cells.
Page 1000
Figure 10

3D radiobiologic dosimetry: Prideaux and colleagues use data from a 131I-treated patient to create radiobiologic modeling that converts the spatial distribution of absorbed dose into biologically effective dose and equivalent uniform dose parameters.
Page 1008

Anti-18F-FACBC dosimetry: Nye and colleagues evaluate the human whole-body radiation burden of anti-18F-FACBC, a recently developed ligand that permits PET evaluation of the L-amino acid transport system.
Page 1017

PET and coronary artery stenosis: Madar and colleagues report on the potential clinical utility of 18F-FBnTP PET in assessing the severity of coronary artery stenosis in a canine model.
Page 1021
Figure 11

Imaging cardiac cell death: Zhu and colleagues characterize the temporal and spatial distribution of a 99mTc-labeled fusion protein of C2A and glutathione-s-transferase in a rat model of myocardial ischemia and reperfusion.
Page 1031
Figure 12


ON THE COVER

18F-FDG PET/CT has been found useful in evaluating hepatocellular carcinoma metastases, although its role in the diagnosis of primary hepatocellular carcinoma is more limited. Dual-tracer PET/CT with 18F-FDG and 11C-acetate has shown an incremental value and a complementary advantage over single-tracer imaging in the evaluation of hepatocellular carcinoma metastases. Some intrathoracic nodes showing increased 18F-FDG activity could be noncalcified granulomatous nodes and, thus, false-positive for metastasis. This possibility can be minimized by correlating serial PET/CT with other ancillary findings.
Figure 13

SEE PAGE 908

 


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123I-ITdU–Mediated Nanoirradiation of DNA Efficiently Induces Cell Kill in HL60 Leukemia Cells and in Doxorubicin-, ß-, or {gamma}-Radiation–Resistant Cell Lines
Sven N. Reske, Sandra Deisenhofer, Gerhard Glatting, Boris D. Zlatopolskiy, Agnieszka Morgenroth, Andreas T. J. Vogg, Andreas K. Buck, and Claudia Friesen
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Aging of Acute Deep Vein Thrombosis Measured by Radiolabeled 99mTc-rt-PA
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Total Thyroidectomy and Adjuvant Radioiodine Treatment Independently Decrease Locoregional Recurrence Risk in Childhood and Adolescent Differentiated Thyroid Cancer
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