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FIGURE 5. Representative competition experiments in human tumor and normal tissues—namely, pheochromocytoma (A), pancreatic islets (B), duodenal Brunner's glands (C), and myenteric nerve plexus of colon (D). In all examples, high-affinity displacement of 125I-GLP-1(7–36)amide by GLP-1 receptor-selective agonists GLP-1(7–36)amide and exendin-4 and low-affinity displacement by GLP-2 receptor-selective agonist GLP-2 and glucagon receptor-selective agonist glucagon(1–29) was evident.
