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FIGURE 3. In vitro receptor autoradiography on human normal tissues. (A and C) Hematoxylin- and eosin-stained (HE) tissue sections show the following: (A) duodenum with Brunner's glands (arrowhead) and overlying mucosa (m) and (C) colon with myenteric nerve plexus (arrowheads), muscularis propria (mp), and mucosa (m). Bars = 1 mm. (B and D) Autoradiograms show total binding of 125I-GLP-1(7–36)amide. (B) Duodenum with very strong specific binding to Brunner's glands (arrowhead). Note that labeling observed in mucosa (m) is nonspecific. (D) Colon with specific binding to myenteric plexus (arrowheads). As in the duodenum, labeling observed in mucosa (m) is nonspecific.
