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FIGURE 1. Algorithm for calculating regional structural volume and glucose metabolism An example of calculating hippocampal volume and metabolism is shown. Hippocampal VOI template is transformed to individual brain and, using this VOI template on individual segmented MR image, hippocampi are extracted and hippocampal volume is calculated. Then, using extracted hippocampi as a hippocampal VOI for individual coregistered PET image, hippocampal counts representing glucose metabolism are determined.
