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Journal of Nuclear Medicine Vol. 48 No. 5 11a-12a
© 2007 by Society of Nuclear Medicine

This Month in JNM

Breathing lessons for PET/CT: Bacharach looks at the trade-offs in switching from stand-alone PET to PET/CT and previews 3 articles in this month's JNM that focus on various challenges of CT-based attenuation correction.
Page 677

Characterizing pulmonary hypertension: Tunariu and colleagues compare the efficacy of ventilation–perfusion scintigraphy with that of CT pulmonary angiography in identifying patients with chronic thromboembolic pulmonary disease and in hastening the initiation of effective therapies.
Page 680

Posthepatectomy liver failure risk: Dinant and colleagues compare the abilities of preoperative hepatobiliary scintigraphy and CT volumetric measurement of future remnant liver to predict postoperative morbidity, organ failure, and mortality in patients undergoing liver resection.
Page 685

Tracer influence on lymphoscintigraphy: Bourgeois evaluates whether and how the volume and quantity of injected 99mTc-labeled colloids––data usually not included in scientific reports––affect lymphoscintigraphic results.
Page 693

Cardiac SPECT/CT fusion: Gaemperli and colleagues report on initial experience with fused 3D SPECT/CT in patients with coronary artery disease and on the potential of this technique for providing incremental diagnostic information on the functional relevance of coronary artery lesions.
Page 696

PET and MRI in mild dementia: Ishii and colleagues investigate regional and patho
Figure 1
physiologic differences in morphologic and functional changes in patients with mild dementia with Lewy bodies and individuals with very early Alzheimer's disease.
Page 704

Deep breath-hold PET/CT: Meirelles and colleagues detail the detection and characterization of thoracic lesions by PET/CT imaging acquired with and without a novel deep-inspiration protocol.
Page 712

18F-TYR PET/CT and meningiomas: Rutten and colleagues describe results with PET/CT and 2-18F-fluoro-L-tyrosine, a marker of amino acid transport, as part of routine yearly follow-up of patients previously irradiated for skull base meningiomas.
Page 720
Figure 2

18F-FLT PET in lymph node staging: Troost and colleagues assess the value of 18F-FLT PET in determining lymph node status in patients with newly diagnosed squamous cell carcinoma of the head and neck.
Page 726
Figure 3

GLP-1 receptors in tumors: Körner and colleagues report on in vitro evaluations of GLP-1 receptor expression in a variety of human tumors and nonneoplastic tissues and discuss the promise of GLP-1 receptors in molecular scintigraphy and targeted radiotherapy.
Page 736
Figure 4

PET predictions in NSCLC: Nahmias and colleagues describe patient studies assessing the ability of 18F-FDG PET to characterize early metabolic response to chemotherapy in patients with non–small cell lung cancer and to predict therapeutic success or failure.
Page 744

PET and treatment prognosis: Kim and colleagues evaluate the effectiveness of pretreatment 18F-FDG PET in providing guidance for choice of initial treatment in patients with squamous cell carcinoma of the oropharynx.
Page 752

Postacquisition motion detection in PET: Bundschuh and colleagues report on the feasibility of a technique using list-mode data to detect craniocaudal movement of thoracic and abdominal lesions in PET imaging without an external gating device.
Page 758

Delayed PET/CT in bladder cancer: Anjos and colleagues investigate the role of delayed 18F-FDG PET/CT in the detection and restaging of bladder cancer, using a diuretic and oral hydration to remove excreted tracer from the bladder.
Page 764

PET and molecular markers: Riedl and colleagues explore the prognostic capabilities of PET by determining the extent to which presurgical 18F-FDG PET images in metastatic colorectal cancer correlate with other cellular characteristics and clinical behaviors of these tumors.
Page 771
Figure 5

Metabolic asymmetry in epilepsy: Lin and colleagues describe an approach to identify and quantify those aspects of metabolic asymmetry in presurgical PET scans that may accurately predict postsurgical seizure-free clinical outcomes in patients with temporal lobe epilepsy.
Page 776
Figure 6

Cardiac PET/CT imaging: Di Carli and colleagues provide an educational overview of the advantages and challenges of myocardial perfusion PET and integrated PET/CT, with a focus on the hybrid technology's potential for translating advances in molecularly targeted imaging to humans.
Page 783

Cine CT in cardiac PET/CT: Alessio and colleagues investigate the use of cine CT, acquiring multiple low-dose CT images during a respiratory cycle, as an alternative to helical CT in cardiac PET attenuation correction.
Page 794
Figure 7

Iterative partial-volume correction: Teo and colleagues describe an iterative postreconstruction method that corrects for partial-volume errors in PET, thereby enhancing the accuracy of radiopharmaceutical uptake estimates in small tumors.
Page 802
Figure 8

CT-corrected canine cardiac PET: Cook and colleagues compare respiration-averaged CT and 4D CT for attenuation correction of cardiac PET in an in vivo canine model.
Page 811

Human-derived PET reporter gene: Ponomarev and colleagues describe preliminary assessment of a human-derived intrinsically nonimmunogenic reporter gene for PET imaging of molecular–genetic processes and discuss potential clinical applications.
Page 819

124I-MIBG hNET reporter gene imaging: Moroz and colleagues detail the construction of a novel internal ribosomal entry site–linked norepinephrine transporter hybrid reporter gene radiolabeled for both nuclear and optical imaging.
Page 827
Figure 9

Quantitative PET with microfluidics: Wu and colleagues describe an automated blood sampling device on an integrated microfluidic platform for precise small-quantity blood withdrawal in PET studies of mice.
Page 837
Figure 10


ON THE COVER

At top left, perfusion polar maps at stress and rest show a largely reversible anteroapical perfusion defect (arrowhead). At top right, 3-dimensional volume-rendered CT angiogram shows the coronary vessel tree with stenosis of the mid left anterior descending artery (LAD) and proximal stenosis of the first diagonal branch (DA1). At bottom left, fused 3-dimensional SPECT/CT image shows that the DA1 stenosis is the functionally relevant lesion. At bottom right, findings are confirmed by invasive coronary angiography.
Figure 11

SEE PAGE 701

 


Related articles in JNM:

PET/CT Attenuation Correction: Breathing Lessons
Stephen L. Bacharach
JNM 2007 48: 677-679. [Full Text]  

Ventilation–Perfusion Scintigraphy Is More Sensitive than Multidetector CTPA in Detecting Chronic Thromboembolic Pulmonary Disease as a Treatable Cause of Pulmonary Hypertension
Nina Tunariu, Simon J.R. Gibbs, Zarni Win, Wendy Gin-Sing, Alison Graham, Philip Gishen, and Adil AL-Nahhas
JNM 2007 48: 680-684. [Abstract] [Full Text]  

Risk Assessment of Posthepatectomy Liver Failure Using Hepatobiliary Scintigraphy and CT Volumetry
Sander Dinant, Wilmar de Graaf, Bart J. Verwer, Roelof J. Bennink, Krijn P. van Lienden, Dirk J. Gouma, Arlène K. van Vliet, and Thomas M. van Gulik
JNM 2007 48: 685-692. [Abstract] [Full Text]  

Scintigraphic Investigations of the Lymphatic System: The Influence of Injected Volume and Quantity of Labeled Colloidal Tracer
Pierre Bourgeois
JNM 2007 48: 693-695. [Abstract] [Full Text]  

Cardiac Image Fusion from Stand-Alone SPECT and CT: Clinical Experience
Oliver Gaemperli, Tiziano Schepis, Ines Valenta, Lars Husmann, Hans Scheffel, Victor Duerst, Franz R. Eberli, Thomas F. Luscher, Hatem Alkadhi, and Philipp A. Kaufmann
JNM 2007 48: 696-703. [Abstract] [Full Text]  

Comparison of Regional Brain Volume and Glucose Metabolism Between Patients with Mild Dementia with Lewy Bodies and Those with Mild Alzheimer's Disease
Kazunari Ishii, Tsutomu Soma, Atsushi K. Kono, Keitaro Sofue, Naokazu Miyamoto, Toshiki Yoshikawa, Etsuro Mori, and Kenya Murase
JNM 2007 48: 704-711. [Abstract] [Full Text]  

Deep-Inspiration Breath-Hold PET/CT: Clinical Findings with a New Technique for Detection and Characterization of Thoracic Lesions
Gustavo S.P. Meirelles, Yusuf Emre Erdi, Sadek A. Nehmeh, Olivia D. Squire, Steven M. Larson, John L. Humm, and Heiko Schöder
JNM 2007 48: 712-719. [Abstract] [Full Text]  

PET/CT of Skull Base Meningiomas Using 2-18F-Fluoro-L-Tyrosine: Initial Report
Isabelle Rutten, Jean-Evrard Cabay, Nadia Withofs, Christian Lemaire, Joel Aerts, Veronique Baart, and Roland Hustinx
JNM 2007 48: 720-725. [Abstract] [Full Text]  

18F-FLT PET Does Not Discriminate Between Reactive and Metastatic Lymph Nodes in Primary Head and Neck Cancer Patients
Esther G.C. Troost, Wouter V. Vogel, Matthias A.W. Merkx, Piet J. Slootweg, Henri A.M. Marres, Wenny J.M. Peeters, Johan Bussink, Albert J. van der Kogel, Wim J.G. Oyen, and Johannes H.A.M. Kaanders
JNM 2007 48: 726-735. [Abstract] [Full Text]  

GLP-1 Receptor Expression in Human Tumors and Human Normal Tissues: Potential for In Vivo Targeting
Meike Körner, Martin Stöckli, Beatrice Waser, and Jean Claude Reubi
JNM 2007 48: 736-743. [Abstract] [Full Text]  

Time Course of Early Response to Chemotherapy in Non–Small Cell Lung Cancer Patients with 18F-FDG PET/CT
Claude Nahmias, Wahid T. Hanna, Lindi M. Wahl, Misty J. Long, Karl F. Hubner, and David W. Townsend
JNM 2007 48: 744-751. [Abstract] [Full Text]  

Use of 18F-FDG PET for Primary Treatment Strategy in Patients with Squamous Cell Carcinoma of the Oropharynx
Sang Yoon Kim, Jong-Lyel Roh, Mi Ra Kim, Jae Seung Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang-wook Lee, and Sung-Bae Kim
JNM 2007 48: 752-757. [Abstract] [Full Text]  

Postacquisition Detection of Tumor Motion in the Lung and Upper Abdomen Using List-Mode PET Data: A Feasibility Study
Ralph A. Bundschuh, Axel Martínez-Moeller, Markus Essler, María-José Martínez, Stephan G. Nekolla, Sibylle I. Ziegler, and Markus Schwaiger
JNM 2007 48: 758-763. [Abstract] [Full Text]  

18F-FDG PET/CT Delayed Images After Diuretic for Restaging Invasive Bladder Cancer
Dalton A. Anjos, Elba C.S.C. Etchebehere, Celso D. Ramos, Allan O. Santos, César Albertotti, and Edwaldo E. Camargo
JNM 2007 48: 764-770. [Abstract] [Full Text]  

18F-FDG PET Scanning Correlates with Tissue Markers of Poor Prognosis and Predicts Mortality for Patients After Liver Resection for Colorectal Metastases
Christopher C. Riedl, Timothy Akhurst, Steven Larson, Stephen F. Stanziale, Scott Tuorto, Amit Bhargava, Hedvig Hricak, David Klimstra, and Yuman Fong
JNM 2007 48: 771-775. [Abstract] [Full Text]  

Predicting Seizure-Free Status for Temporal Lobe Epilepsy Patients Undergoing Surgery: Prognostic Value of Quantifying Maximal Metabolic Asymmetry Extending over a Specified Proportion of the Temporal Lobe
Tina W. Lin, Michelle A. Kung de Aburto, Magnus Dahlbom, Lynn L. Huang, Michael M. Marvi, Michael Tang, Johannes Czernin, Michael E. Phelps, and Daniel H.S. Silverman
JNM 2007 48: 776-782. [Abstract] [Full Text]  

Clinical Myocardial Perfusion PET/CT
Marcelo F. Di Carli, Sharmila Dorbala, Jolene Meserve, Georges El Fakhri, Arkadiusz Sitek, and Stephen C. Moore
JNM 2007 48: 783-793. [Abstract] [Full Text]  

Cine CT for Attenuation Correction in Cardiac PET/CT
Adam M. Alessio, Steve Kohlmyer, Kelley Branch, Grace Chen, James Caldwell, and Paul Kinahan
JNM 2007 48: 794-801. [Abstract] [Full Text]  

Partial-Volume Correction in PET: Validation of an Iterative Postreconstruction Method with Phantom and Patient Data
Boon-Keng Teo, Youngho Seo, Stephen L. Bacharach, Jorge A. Carrasquillo, Steven K. Libutti, Himanshu Shukla, Bruce H. Hasegawa, Randall A. Hawkins, and Benjamin L. Franc
JNM 2007 48: 802-810. [Abstract] [Full Text]  

Respiration-Averaged CT for Attenuation Correction in Canine Cardiac PET/CT
Russell A.H. Cook, Greg Carnes, Ting-Yim Lee, and R. Glenn Wells
JNM 2007 48: 811-818. [Abstract] [Full Text]  

A Human-Derived Reporter Gene for Noninvasive Imaging in Humans: Mitochondrial Thymidine Kinase Type 2
Vladimir Ponomarev, Michael Doubrovin, Aleksander Shavrin, Inna Serganova, Tatiana Beresten, Ludmila Ageyeva, Changde Cai, Julius Balatoni, Mian Alauddin, and Juri Gelovani
JNM 2007 48: 819-826. [Abstract] [Full Text]  

Imaging hNET Reporter Gene Expression with 124I-MIBG
Maxim A. Moroz, Inna Serganova, Pat Zanzonico, Ludmila Ageyeva, Tatiana Beresten, Ekaterina Dyomina, Eva Burnazi, Ronald D. Finn, Michael Doubrovin, and Ronald G. Blasberg
JNM 2007 48: 827-836. [Abstract] [Full Text]  

In Vivo Quantitation of Glucose Metabolism in Mice Using Small-Animal PET and a Microfluidic Device
Hsiao-Ming Wu, Guodong Sui, Cheng-Chung Lee, Mayumi L. Prins, Waldemar Ladno, Hong-Dun Lin, Amy S. Yu, Michael E. Phelps, and Sung-Cheng Huang
JNM 2007 48: 837-845. [Abstract] [Full Text]  




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