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FIGURE 1. Dual-isotope imaging using 201Tl for left ventricular contour detection and, simultaneously, radiolabeled annexin A5 in patients with dilated cardiomyopathy. (A) Dilated cardiomyopathy patient with rapid deterioration of left ventricular function. Note focal uptake in apex and lateral wall, and slight septal uptake. (B) Dilated cardiomyopathy patient in acute heart failure. Note global uptake of radiolabeled annexin A5. (C) Dilated cardiomyopathy patient in stable clinical condition. Uptake is absent even when image is enhanced to the extent that background radioactivity can be observed. (D) Family member of patient in panel B. No clinical evidence is seen of dilated cardiomyopathy. Note absence of uptake of radiolabeled annexin A5. ANT = anterior; INF = inferior; LAT = lateral; SEPT = septal.
