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FIGURE 3. In vivo binding of BF-227 to amyloid plaques in PS1/APP transgenic mouse. In brain sections from PS1/APP transgenic mouse after intravenous injection of 4 mg/kg BF-227, numerous fluorescent spots were observed in neocortex and hippocampus of brain (A and B). In contrast, no fluorescent spots were observed in brain of wild-type mouse (C). Distribution of plaques labeled with BF-227 corresponded well with Aß immunostaining in same section (B and D, arrowheads).
