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FIGURE 2. Neuropathologic staining of human brain sections by BF-227. Amyloid plaques are clearly stained with BF-227 in AD temporal brain sections (A). BF-227 staining correlates well with Aß immunostaining in adjacent sections (B, arrows). BF-227 faintly stains NFTs, in contrast to clear staining with thioflavin-S (C, arrowheads). In aged normal temporal cortex (D), no staining by BF-227 is observed. Bar in AC = 50 µm; bar in D = 200 µm.
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