Click on image to view larger version.
FIGURE 3. Pharmacokinetics of 111In-ChL6 bioprobes in mice with HBT3477 human breast cancer xenografts. (A) Blood clearance of 111In-ChL6 bioprobes (•) was more rapid than that of 111In-ChL6 mAb alone (
). Whole-body clearances (
, 
) were similar. (B) Concentrations (%ID/g) of 111In-ChL6 bioprobes in blood, tumor, liver, lung, kidneys, spleen, and marrow at 1 d (
), 2 d (
), 3 d (
), and 4 d (
) after injection. Maximum concentrations in liver and spleen were almost twice and tumor concentration was about 75% of that previously observed for 111In-ChL6 mAb (16). Concentrations of 111In in other normal tissues were similar to those of 111In-ChL6 mAb.
