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FIGURE 7. Effect of ATRA on radioiodine uptake in MCF-7 cells. 125I uptake in wild-type MCF-7 cells increased by 3.1-, 5.5-, and 7.6-fold with treatment of 10–8, 10–7, and 10–6 mol/L ATRA, respectively. Treatment with 0, 10–8, 10–7, and 10–6 mol/L ATRA in Rad-NIS–infected cells increased 125I uptake by 4.0-, 4.9-, 8.2-, and 27.6-fold greater than that in wild-type MCF-7 cells. Rad-NIS–infected MCF-7 cells with 10–6 mol/L ATRA treatment (245.0 ± 13.7 pmol/106 cells) is much greater than the sum of levels seen with ATRA treatment and Rad-NIS infection alone. RA = retinoic acid.
