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Figure 4


FIGURE 4.  Effect of ATRA treatment on NIS protein expression in MCF-7 cells assessed by Western blot analysis. Main immunoreactive protein in MCF-7 cells, ~90 kDa, increased with ATRA treatment combined with adenoviral gene transfer. ATRA significantly increased expression in dose-dependent manner in cells infected with adenoviruses carrying NIS. However, wild-type MCF-7 cells showed only faint NIS expression despite ATRA treatment. hNIS = human NIS.





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