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FIGURE 5. (A and B) Agreement between extent of CAD determined by coronary angiography (x-axis) and myocardial perfusion defects alone (A) and by combined myocardial perfusion defects and abnormal LVEF reserve (B). No patients demonstrated defects in 3-vessel distribution. Disease extent was underestimated in half of patients with severe left main/3-vessel disease (no defects in 7% and defect in 1-vessel distribution in 43%). By combining perfusion and LVEF reserve, no patients were missed and most patients were correctly classified as having left main/3-vessel disease (86%).