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FIGURE 2. Proposed design of randomized trials evaluating impact of PET on disease management. Patients were randomized to either standard therapy (A) or PET-controlled therapy (B). For group B, treatment was changed on basis of tumor response after brief period of therapy. Metabolic responders (as determined by PET) continued to receive standard therapy, whereas treatment was changed for metabolic nonresponders. Effect of this change in therapy was evaluated by comparing survival, morbidity, and treatment-related costs in arms A and B.
