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Journal of Nuclear Medicine Vol. 48 No. 10 11A-12A
© 2007 by Society of Nuclear Medicine

This Month in JNM

18F-DOPA PET applications: Nanni and colleagues provide an overview of the use of 18F-DOPA in PET and PET/CT imaging for neurologic and oncologic indications and preview a related article in this issue of JNM.
Page 1577

Qualitative and quantitative PET in lymphoma: Weber looks at the success of 18F-FDG PET in assessment of tumor response to chemotherapy for Hodgkin's and non-Hodgkin's lymphoma and considers the advantages of adding quantitative parameters to visual assessment.
Page 1580

Limitations of CT in PET/CT: Gollub and colleagues explore the technical causes and diagnostic significance of missed findings in the unenhanced CT portion of PET/CT scans.
Page 1583

PET response evaluation for NSCLC: de Geus-Oei and colleagues assess the value of 18F-FDG PET in predicting chemotherapy response in patients with non–small cell lung cancer and compare 2 methods for quantifying changes in glucose metabolism in such studies.
Page 1592

Carbidopa 18F-DOPA PET in paraganglioma: Timmers and colleagues investigate the sensitivity of 18F-DOPA PET in the detection of paraganglioma and its metastatic lesions and evaluate whether tracer uptake by tumors is enhanced by carbidopa.
Page 1599
Figure 1

Interval sentinel lymph nodes and melanoma: Matter and colleagues review the incidence, lymphatic anatomy, and metastatic risk of interval sentinel nodes, as well as the role of preoperative lymphoscintigraphy in reviewing all known lymphatic areas.
Page 1607
Figure 2

PET staging of nasopharyngeal cancer: Liu and colleagues provide evidence that 18F-FDG PET can replace multimodality conventional work-ups in primary staging of patients with nonkeratinizing nasopharyngeal carcinoma.
Page 1614
Figure 3

Dental effects of radioiodine therapy: Walter and colleagues investigate the long-term incidence of dental problems after high-dose 131I therapy for differentiated thyroid cancer and describe associated risk factors.
Page 1620

Early SUV assessment in lymphoma: Lin and colleagues assess the prognostic value of standardized uptake values in early 18F-FDG PET imaging in patients with diffuse large B-cell lymphoma and compare their results with those from routine visual analysis.
Page 1626
Figure 4

Nicotinic receptor availability in nonsmokers: Cosgrove and colleagues use SPECT and MRI to examine the availability of nicotinic acetylcholine receptors in healthy men and women and assess whether menstrual phase in women affects these findings.
Page 1633

Perspectives on dementia: Inui and colleagues assess a combined SPECT approach using 123I-IMP for brain perfusion imaging, 123I-MIBG for cardiac sympathetic nerve function, and 99mTc-sestamibi for myocardial function in patients with probable or possible dementia with Lewy bodies.
Page 1641
Figure 5

18F-FDOPA kinetics in brain tumors: Schiepers and colleagues investigate the action of this amino acid analog using PET in patients with brain tumors to derive a useful clinical model of uptake for different types of neoplasms.
Page 1651
Figure 6

Variable cardiac uptake in oncology PET: Inglese and colleagues analyze global and regional 18F-FDG cardiac images in fasted cancer patients free from cardiac disease and offer a word of caution on the diagnosis of myocardial scar in such patients.
Page 1662
Figure 7

Early tetrofosmin imaging: Rossi and colleagues, representing the multicenter Myoview Imaging Optimization study, assess whether early myocardial tetrofosmin SPECT imaging is feasible and as accurate as standard delayed imaging in detecting coronary artery disease in patients with anginal symptoms.
Page 1670

Nicorandil therapy in acute MI: Kasama and colleagues use 123I-MIBG scintigraphy to explore the long-term effects of this adenosine triphosphate–sensitive potassium channel opener in patients with acute myocardial infarction.
Page 1676

Bystander and low–dose rate effects: Sgouros and colleagues provide an educational overview of the history, key experiments, and current understanding of these radiation-induced effects and pose questions about their relevance in radionuclide therapy.
Page 1683

Weak sources in PET: Goertzen and colleagues evaluate the potential effects of intrinsic radioactivity in lutetium oxyorthosilicate–based small-animal PET imaging and offer advice on strategies for visualizing weak sources in these scanners.
Page 1692
Figure 8

PET in breast cell proliferation: Tian and colleagues report on PET imaging and quantitation with a dual-specificity probe that molecularly targets both CCND1 mRNA and insulinlike growth factor 1 receptor in early breast cancer.
Page 1699
Figure 9

Dynamic tracking of cell therapy: Doyle and colleagues study the feasibility of dynamic 3D-PET/CT tracking of 18F-FDG–labeled circulating progenitor cell therapy during intracoronary injection in a swine model of acute myocardial infarction.
Page 1708
Figure 10

Uptake of tracers into brown fat: Baba and colleagues determine whether multiple clinically useful radiotracers accumulate in brown adipose tissue and assess the uptake of these tracers in rats kept in normal and cold environments.
Page 1715
Figure 11

PET and methamphetamine effects: Fowler and colleagues measure the pharmacokinetics of two 11C-labeled methamphetamine enantiomers in the baboon brain and peripheral organs to assess the saturability and pharmacologic specificity of binding.
Page 1724
Figure 12

HED retention in noncardiac tissues: Thackeray and colleagues explore the retention of 11C-meta-hydroxyephedrine in brown adipose tissue, lung, pancreas, skeletal muscle, and kidney and discuss the potential for novel PET studies of sympathetic nervous system integrity in these tissues.
Page 1733

68Ge/Ga generator postprocessing: Zhernosekov and colleagues describe an efficient method for processing generator-derived 68Ga eluates, including the labeling and purification of biomolecules, for radiopharmaceuticals for routine applications.
Page 1741


ON THE COVER

Mean parametric images illustrating 123I-5-IA-85380 activity in 10 men and 19 women in VT' (regional activity divided by total plasma parent between 6 and 8 h) and VT (regional activity divided by free plasma parent between 6 and 8 h). Across brain regions, the main VT' component was significantly greater in women than in men, but the main VT component did not significantly differ between the sexes.
Figure 13

See page 1637.

 


Related articles in JNM:

18F-DOPA PET and PET/CT
Cristina Nanni, Stefano Fanti, and Domenico Rubello
JNM 2007 48: 1577-1579. [Full Text]  

18F-FDG PET in Non-Hodgkin's Lymphoma: Qualitative or Quantitative?
Wolfgang A. Weber
JNM 2007 48: 1580-1582. [Full Text]  

Limitations of CT During PET/CT
Marc J. Gollub, Richard Hong, Debra M. Sarasohn, and Tim Akhurst
JNM 2007 48: 1583-1591. [Abstract] [Full Text]  

Chemotherapy Response Evaluation with 18F-FDG PET in Patients with Non-Small Cell Lung Cancer
Lioe-Fee de Geus-Oei, Henricus F.M. van der Heijden, Eric P. Visser, Rick Hermsen, Bas A. van Hoorn, Johanna N.H. Timmer-Bonte, Antoon T. Willemsen, Jan Pruim, Frans H.M. Corstens, Paul F.M. Krabbe, and Wim J.G. Oyen
JNM 2007 48: 1592-1598. [Abstract] [Full Text]  

The Effects of Carbidopa on Uptake of 6-18F-Fluoro-L-DOPA in PET of Pheochromocytoma and Extraadrenal Abdominal Paraganglioma
Henri J.L.M. Timmers, Mohiuddin Hadi, Jorge A. Carrasquillo, Clara C. Chen, Lucia Martiniova, Millie Whatley, Alexander Ling, Graeme Eisenhofer, Karen T. Adams, and Karel Pacak
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The Role of Interval Nodes in Sentinel Lymph Node Mapping and Dissection for Melanoma Patients
Maurice Matter, Marie Nicod Lalonde, Mohamed Allaoua, Ariane Boubaker, Danielle Liénard, Oliver Gugerli, Jean-Philippe Cerottini, Hanifa Bouzourene, Angelika Bischof Delaloye, and Ferdinand Lejeune
JNM 2007 48: 1607-1613. [Abstract] [Full Text]  

18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma
Feng-Yuan Liu, Chien-Yu Lin, Joseph T. Chang, Shu-Hang Ng, Shy-Chyi Chin, Hung-Ming Wang, Chun-Ta Liao, Sheng-Chieh Chan, and Tzu-Chen Yen
JNM 2007 48: 1614-1619. [Abstract] [Full Text]  

The Dental Safety Profile of High-Dose Radioiodine Therapy for Thyroid Cancer: Long-Term Results of a Longitudinal Cohort Study
Martin A. Walter, Christian P. Turtschi, Christian Schindler, Peter Minnig, Jan Müller-Brand, and Beat Müller
JNM 2007 48: 1620-1625. [Abstract] [Full Text]  

Early 18F-FDG PET for Prediction of Prognosis in Patients with Diffuse Large B-Cell Lymphoma: SUV-Based Assessment Versus Visual Analysis
Chieh Lin, Emmanuel Itti, Corinne Haioun, Yolande Petegnief, Alain Luciani, Jehan Dupuis, Gaetano Paone, Jean-Noël Talbot, Alain Rahmouni, and Michel Meignan
JNM 2007 48: 1626-1632. [Abstract] [Full Text]  

123I-5-IA-85380 SPECT Imaging of Nicotinic Acetylcholine Receptor Availability in Nonsmokers: Effects of Sex and Menstrual Phase
Kelly P. Cosgrove, Effie M. Mitsis, Frederic Bois, Erin Frohlich, Gilles D. Tamagnan, Erica Krantzler, Edward Perry, Paul K. Maciejewski, C. Neill Epperson, Sharon Allen, Stephanie O'Malley, Carolyn M. Mazure, John P. Seibyl, Christopher H. van Dyck, and Julie K. Staley
JNM 2007 48: 1633-1640. [Abstract] [Full Text]  

Evaluation of Probable or Possible Dementia with Lewy Bodies Using 123I-IMP Brain Perfusion SPECT, 123I-MIBG, and 99mTc-MIBI Myocardial SPECT
Yoshitaka Inui, Hiroshi Toyama, Yuta Manabe, Takahisa Sato, Masayoshi Sarai, Kenji Kosaka, Nakao Iwata, and Kazuhiro Katada
JNM 2007 48: 1641-1650. [Abstract] [Full Text]  

18F-FDOPA Kinetics in Brain Tumors
Christiaan Schiepers, Wei Chen, Timothy Cloughesy, Magnus Dahlbom, and Sung-Cheng Huang
JNM 2007 48: 1651-1661. [Abstract] [Full Text]  

Spatial and Temporal Heterogeneity of Regional Myocardial Uptake in Patients Without Heart Disease Under Fasting Conditions on Repeated Whole-Body 18F-FDG PET/CT
Eugenio Inglese, Lucia Leva, Roberta Matheoud, Gianmauro Sacchetti, Chiara Secco, Patrizia Gandolfo, Marco Brambilla, and Gianmario Sambuceti
JNM 2007 48: 1662-1669. [Abstract] [Full Text]  

Feasibility and Diagnostic Accuracy of a Gated SPECT Early-Imaging Protocol: A Multicenter Study of the Myoview Imaging Optimization Group
Assuero Giorgetti, Massimiliano Rossi, Mario Stanislao, Guido Valle, Pietro Bertolaccini, Alberto Maneschi, Raffaele Giubbini, Maria Luisa De Rimini, Marco Mazzanti, Mario Cappagli, Elisa Milan, Duccio Volterrani, Paolo Marzullo, and on behalf of the Myoview Imaging Optimization group
JNM 2007 48: 1670-1675. [Abstract] [Full Text]  

Long-Term Nicorandil Therapy Improves Cardiac Sympathetic Nerve Activity After Reperfusion Therapy in Patients with First Acute Myocardial Infarction
Shu Kasama, Takuji Toyama, Hiroyuki Sumino, Hisao Kumakura, Yoshiaki Takayama, Shuichi Ichikawa, Tadashi Suzuki, and Masahiko Kurabayashi
JNM 2007 48: 1676-1682. [Abstract] [Full Text]  

MIRD Continuing Education: Bystander and Low–Dose-Rate Effects: Are These Relevant to Radionuclide Therapy?
George Sgouros, Susan J. Knox, Michael C. Joiner, William F. Morgan, and Amin I. Kassis
JNM 2007 48: 1683-1691. [Abstract] [Full Text]  

Imaging of Weak-Source Distributions in LSO-Based Small-Animal PET Scanners
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JNM 2007 48: 1692-1698. [Abstract] [Full Text]  

PET Imaging of CCND1 mRNA in Human MCF7 Estrogen Receptor–Positive Breast Cancer Xenografts with Oncogene-Specific [64Cu]Chelator-Peptide Nucleic Acid-IGF1 Analog Radiohybridization Probes
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JNM 2007 48: 1699-1707. [Abstract] [Full Text]  

Dynamic Tracking During Intracoronary Injection of 18F-FDG-Labeled Progenitor Cell Therapy for Acute Myocardial Infarction
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JNM 2007 48: 1708-1714. [Abstract] [Full Text]  

Comparison of Uptake of Multiple Clinical Radiotracers into Brown Adipose Tissue Under Cold-Stimulated and Nonstimulated Conditions
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JNM 2007 48: 1715-1723. [Abstract] [Full Text]  

PET Studies of d-Methamphetamine Pharmacokinetics in Primates: Comparison with l-Methamphetamine and (–)-Cocaine
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JNM 2007 48: 1724-1732. [Abstract] [Full Text]  

Presence of Specific 11C-meta-Hydroxyephedrine Retention in Heart, Lung, Pancreas, and Brown Adipose Tissue
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Processing of Generator-Produced 68Ga for Medical Application
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