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FIGURE 4.  Time–activity curves extracted from [¹¹C]-(R)-PK11195 dynamic scan of HD patient. ROIs were drawn on areas where high density of PBBS related to microglia activation was expected (caudate, putamen, and globus pallidus), whole gray and white matter. Activity in gray matter reference region and in blood fraction region as extracted by supervised clustering is illustrated. Time–activity curves are decay corrected.

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