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FIGURE 3. HD patient. (A) Map of gray matter reference region extracted by supervised algorithm as overlaid on the coregistered MR image. (B) Map of high PBBS density class. It includes voxels belonging to striatum and frontal cortex (arrows), where microglia activation is expected. (C) Maximum-intensity rendering of blood fraction cluster. Both posterior (left) and lateral (right) views are shown. Note clear detection of venous system but also of major arteries (arrow points to anterior cerebral artery).