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FIGURE 5. ROC curve analysis for early SUV changes in discriminating responder and nonresponder patients. Cutoff value in SUV-mean (closed circles) change of –52% yields values of 100% in sensitivity and specificity, whereas cutoff value in SUV-max (open boxes) of –42% gives a sensitivity of 100% and a specificity of 87% (area under curve, 0.95; confidence interval, 95%).

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