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FIGURE 6. Virtual colonoscopy using supine and prone PET/CT with air insufflation. (A) Supine PET/CT without air insufflation showing abnormal focus (arrows) in rectosigmoid colon on PET. (B) Prone PET and CT with air insufflation providing excellent definition of same lesion shown in A on both PET and CT images. (C) PET/CT without air insufflation illustrating good image and lesion (arrow) coregistration. (D) 3D-rendered PET/CT colonography demonstrating lesion in its entirety.