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FIGURE 5. 3D-rendered PET/CT fly-around aiding spatial localization of metastatic lymph nodes. (A, B, and D) Standard 2D tomographic 18F-FDG PET/CT images illustrating abnormal focus in left side of mediastinum, posterior to left bronchus (demarcated by red cross-hairs). Despite coregistration of focus to contrast-enhanced thin-slice CT, it was difficult to detect and spatially localize lesion. (C) External 3D-rendered PET/CT fly-around showing abnormal 18F-FDG PET focus hidden behind left mainstem bronchus, as well as several additional perihilar 18F-FDGavid lymph nodes. This image allowed clear spatial localization of lesion and guided mediastinoscopy biopsy. LN = lymph node.