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FIGURE 3. CT virtual colonoscopy compared with PET/CT virtual colonoscopy for detection of a potentially malignant lesion. (A) CT-based virtual colonoscopy showing several areas of stool that are difficult to distinguish from potential malignant polyp. (B) PET/CT virtual colonoscopy showing intense 18F-FDG uptake that highlights suspected polyp relative to surrounding stool and greatly aids in differentiation of lesion from stool. (C and D) Retrospective review of standard 2D PET/CT tomographic slices reveals abnormal focus in colon that was missed on original interpretation (C) and would not have been detected without 3D fusion rendering (D). p = polyp; s = stool.