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FIGURE 7. 64Cu-ATSM distribution in response to oxygenation. FSA-bearing rats breathed carbogen for 3 h before and during microPET. (A) 64Cu-ATSM autoradiography image. (B) EF5 binding (orange) and Hoechst perfusion (blue) fluorescent staining image for the neighboring tumor section from same animal. There is no correlation between 64Cu-ATSM uptake and hypoxia marked by EF5 binding. A significant decrease in EF5 staining, but not uptake of 64Cu-ATSM, was found in carbogen-breathing animal group (Table 3).
