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FIGURE 2. Process flow of automated algorithm for detecting match defects: patient with heterogeneous ventilation (A) and perfusion (B) due to severe chronic obstructive pulmonary disease. After normalization, registration, inversion, and subtraction, image contains only match defects (C = AInverse – B). To improve topographic orientation, the subtracted image (C) is fused with the perfusion scan (D = C + B). Multiple match defects in both lungs are displayed in yellow (D). An exemplary coronal slice is shown.
