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FIGURE 1.  Process flow of automated algorithm for detecting mismatch defects. Although ventilation (A) shows no pathologic changes, a substantial defect can be found on the perfusion scan (B). After registration, normalization, and subtraction, the image contains only mismatch defects (C = A – B). To improve topographic orientation, the subtracted image (C) is fused with the perfusion scan (D = C + B). An exemplary coronal slice is shown.

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