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FIGURE 4. (A) Anteroposterior images of an ApoE–/– mouse on Western Diet with experimental atherosclerotic lesion in left leg (red arrows) and sham-operated right leg (yellow arrows) injected with NSB control followed by 
15 MBq of 99mTc-DTPA–Suc-PL14.6 kDa. The 50-min postpolymer injection image is on left and 2-h image is on right. (B) Anteroposterior images of another ApoE–/– mouse injected with bispecific antibody followed by 99mTc-DTPA–Suc-PL14.6 kDa injection. Top left image was obtained at injection and diagram of various organ activities is in top right. Bottom left image is 30-min image after injection of radiolabeled polymer and bottom right image is 3-h image. Red arrows denote lesion site and yellow arrows denote sham-operated site. (C) Image of another ApoE–/– mouse with experimental atherosclerotic lesion 2 h after injection of 99mTc-DTPA–Suc-PL14.6 kDa. Red arrow = lesion; yellow arrow = sham-operated site.
