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FIGURE 4. Compartmental analysis allows simulation of time courses for each compartment: free/nonspecifically bound and specifically bound ligand for 123I-IMZ (A and B) and FMZ (C and D). The first column corresponds to protocol 1 and the second column corresponds to protocol 2. Only the labeled input function of the model is represented here. Estimated IMZ model parameters were as follows: for A and C, B'max = 53 ± 1 pmol/mL, K1 = 0.54 ± 0.01 min–1, k'2 = 0.19 ± 0.01 min–1, kon/VR = 0.071 ± 0.003 mL/pmol·min, koff = 0.18 ± 0.01 min–1; and for B and D, B'max = 44 ± 2 pmol/mL, K1 = 0.44 ± 0.01 min–1, k2 = 0.20 ± 0.01 min–1, kon/VR = 0.100 ± 0.003 mL/pmol·min, koff = 0.24 ± 0.01 min–1.
