Journal of Nuclear Medicine Vol. 47 No. 4 9a-10a
© 2006 by Society of Nuclear Medicine
This Month in JNM
Gambhir reviews the use of aptamers as novel imaging probes and previews an article in this issue of JNM on tumor targeting in a small-animal model.
Page 557
Prévost and colleagues evaluate the effectiveness of 18F-FDG PET measures of diffuse bone marrow hypermetabolism and other factors in predicting outcomes in patients with non–small cell lung cancer.
Page 559
Meisetschläger and colleagues compare the pharmacokinetics, biodistribution, and diagnostic performance of a recently introduced 18F-labeled PET tracer for somatostatin receptor (sstr) imaging with 111In-DTPA-octreotide in a population of patients with sstr-positive tumors.
Page 566
Beeres and colleagues use both 99mTc-tetrofosmin SPECT and 18F-FDG SPECT to investigate the effects of autologous bone marrow–derived mononuclear cell injection into the myocardium of patients with drug-refractory ischemia.
Page 574
Moore and colleagues apply whole-body and static 
-camera imaging to evaluate the accuracy of measurements of whole-skeleton 99mTc-MDP plasma clearance obtained using the area-under-the-curve method.
Page 581
Bar-Shalom and colleagues explore the role of SPECT/CT as an adjunct to 67Ga scintigraphy or 111In-labeled white blood cell scintigraphy for diagnosis or localization of suspected infection.
Page 587
Funk and colleagues report on a novel multipinhole collimator to improve detection efficiency in cardiac SPECT and detail significant advantages over rotational SPECT with conventional parallel-hole collimators.
Page 595
Engles and colleagues describe a transient "stunning" effect after chemotherapy for breast cancer and discuss potential implications for 3H-FDG PET imaging.
Page 603
Choi and colleagues assess whether 18F-FDG uptake patterns and CT findings improve accuracy over standardized uptake values alone in differentiating benign from malignant focal thyroid lesions incidentally found on 18F-FDG PET/CT.
Page 609
Palmedo and colleagues document the diagnostic accuracy and effect on patient management of PET/CT in patients with suspected iodine-negative, differentiated thyroid carcinoma and compare these results with those obtained by side-by-side interpretation of PET and CT images.
Page 616
Dumarey and colleagues investigate the feasibility and potential role of PET/CT with 18F-FDG–labeled autologous leukocytes in the diagnosis and localization of infectious lesions in patients with suspected or documented bacterial infections or with fevers of unknown origin.
Page 625
Nishiyama and colleagues evaluate the efficacy of dual-time-point 18F-FDG PET imaging for differentiating malignant from benign gallbladder disease and discuss the limitations and benefits of this approach.
Page 633
Pichler and colleagues describe the initial development of a lutetium oxyorthosilicate–avalanche photodiode array detector PET module to be combined with a 7-T MRI system for high-resolution PET/MRI in small animals.
Page 639
Hänscheid and colleagues report on an international study of postoperative radioiodine ablation therapy with 3.7 GBq of 131I in differentiated thyroid cancer after stimulation with recombinant human thyroid-stimulating hormone or after thyroid hormone withdrawal.
Page 648
Stabin and colleagues provide dose factors for internal sources in realistic, segmented, voxel-based models of a typical mouse and typical rat, based on image data obtained using a dedicated small-animal CT scanner.
Page 655
Madsen and colleagues devise a theoretical model to investigate the potential incremental value of combined-agent 131I-MIBG and 90Y-DOTATOC therapy in neuroendocrine tumors.
Page 660
Hicke and colleagues describe a novel approach to assess whether aptamers, small oligonucleotides with the potential to bind tightly to targeted molecules, have potential for in vivo delivery of radioisotopes or cytotoxic agents.
Page 668
Tsukada and colleagues compare the tumor imaging capabilities of the L- and D-isomers of 11C-CMT and 18F-FMT with corresponding 11C-MET isomers and discuss the potential implications of their results for imaging of cerebral and peripheral tumors.
Page 679
Welch and colleagues report on a study to determine whether kinetic modeling in conjunction with small-animal PET can noninvasively quantify alterations in myocardial perfusion and substrate metabolism in a rat model.
Page 689
Ametamey and colleagues evaluate 11C-ABO688, a novel antagonist for the metabotropic glutamate receptor subtype 5, as a PET imaging agent in a mouse brain model and point to potential applications in diagnosis and therapy.
Page 698
Yaghoubi and colleagues present the results of a toxicity evaluation of FHBG, which, when labeled with 18F, is a sensitive and specific PET reporter probe for imaging hepatocellular cancer and has been approved as an Investigational New Drug.
Page 706
Kelly and colleagues explore the biodistribution and therapeutic efficacy of a combined 90Y-labeled monoclonal antibody and paclitaxel regimen in a mouse model of breast cancer.
Page 716
| ON THE COVER
A 58-y-old patient who had been treated 2 y earlier with total thyroidectomy and ablative radioiodine for oxyphilic follicular thyroid carcinoma presented with a markedly elevated thyroglobulin level but no iodine accumulation. Fine-needle aspiration biopsy of a suggestive cervical lymph node revealed tumor cells. Preoperative PET showed intense 18F-FDG uptake in that lymph node, as demonstrated in a coronal slice (top). However, on a transverse slice (second from top), PET detected a second tumor that was more caudal and for which the CT image (third from top) revealed no corresponding abnormality. Only by fusion of the PET and CT images (bottom) could the second tumor be precisely localized and surgically removed.
SEE PAGE 621
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Related articles in JNM:
- Using Radiolabeled DNA as an Imaging Agent to Recognize Protein Targets
- Sanjiv Sam Gambhir
JNM 2006 47: 557-558.
[Full Text]
- Bone Marrow Hypermetabolism on 18F-FDG PET as a Survival Prognostic Factor in Non–Small Cell Lung Cancer
- Sylvain Prévost, Luc Boucher, Pierre Larivée, Robert Boileau, and François Bénard
JNM 2006 47: 559-565.
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- Gluc-Lys([18F]FP)-TOCA PET in Patients with SSTR-Positive Tumors: Biodistribution and Diagnostic Evaluation Compared with [111In]DTPA-Octreotide
- Günther Meisetschläger, Thorsten Poethko, Alexander Stahl, Ingo Wolf, Klemens Scheidhauer, Margret Schottelius, Michael Herz, Hans J. Wester, and Markus Schwaiger
JNM 2006 47: 566-573.
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- Effect of Intramyocardial Injection of Autologous Bone Marrow–Derived Mononuclear Cells on Perfusion, Function, and Viability in Patients with Drug-Refractory Chronic Ischemia
- Saskia L.M.A. Beeres, Jeroen J. Bax, Petra Dibbets, Marcel P.M. Stokkel, Katja Zeppenfeld, Willem E. Fibbe, Ernst E. van der Wall, Martin J. Schalij, and Douwe E. Atsma
JNM 2006 47: 574-580.
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- Validation of a Blood-Sampling Method for the Measurement of 99mTc-Methylene Diphosphonate Skeletal Plasma Clearance
- Amelia E.B. Moore, Glen M. Blake, and Ignac Fogelman
JNM 2006 47: 581-586.
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- SPECT/CT Using 67Ga and 111In-Labeled Leukocyte Scintigraphy for Diagnosis of Infection
- Rachel Bar-Shalom, Nikolay Yefremov, Luda Guralnik, Zohar Keidar, Ahuva Engel, Samy Nitecki, and Ora Israel
JNM 2006 47: 587-594.
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- A Novel Approach to Multipinhole SPECT for Myocardial Perfusion Imaging
- Tobias Funk, Dennis L. Kirch, John E. Koss, Elias Botvinick, and Bruce H. Hasegawa
JNM 2006 47: 595-602.
[Abstract]
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- Stunning and Its Effect on 3H-FDG Uptake and Key Gene Expression in Breast Cancer Cells Undergoing Chemotherapy
- James M. Engles, Shelley A. Quarless, Elizabeth Mambo, Takayoshi Ishimori, Steve Y. Cho, and Richard L. Wahl
JNM 2006 47: 603-608.
[Abstract]
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- Focal Thyroid Lesions Incidentally Identified by Integrated 18F-FDG PET/CT: Clinical Significance and Improved Characterization
- Joon Young Choi, Kyung Soo Lee, Hyung-Jin Kim, Young Mog Shim, O. Jung Kwon, Keunchil Park, Chung-Hwan Baek, Jae Hoon Chung, Kyung-Han Lee, and Byung-Tae Kim
JNM 2006 47: 609-615.
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- Integrated PET/CT in Differentiated Thyroid Cancer: Diagnostic Accuracy and Impact on Patient Management
- Holger Palmedo, Jan Bucerius, Alexius Joe, Holger Strunk, Niclas Hortling, Susanne Meyka, Roland Roedel, Martin Wolff, Eva Wardelmann, Hans-Juergen Biersack, and Ursula Jaeger
JNM 2006 47: 616-624.
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- Imaging Infection with 18F-FDG–Labeled Leukocyte PET/CT: Initial Experience in 21 Patients
- Nicolas Dumarey, Dominique Egrise, Didier Blocklet, Bernard Stallenberg, Myriam Remmelink, Véronique del Marmol, Gaëtan Van Simaeys, Frédérique Jacobs, and Serge Goldman
JNM 2006 47: 625-632.
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- Dual-Time-Point 18F-FDG PET for the Evaluation of Gallbladder Carcinoma
- Yoshihiro Nishiyama, Yuka Yamamoto, Kotaro Fukunaga, Naruhide Kimura, Akihiro Miki, Yasuhiro Sasakawa, Hisao Wakabayashi, Katashi Satoh, and Motoomi Ohkawa
JNM 2006 47: 633-638.
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- Performance Test of an LSO-APD Detector in a 7-T MRI Scanner for Simultaneous PET/MRI
- Bernd J. Pichler, Martin S. Judenhofer, Ciprian Catana, Jeffrey H. Walton, Manfred Kneilling, Robert E. Nutt, Stefan B. Siegel, Claus D. Claussen, and Simon R. Cherry
JNM 2006 47: 639-647.
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- Iodine Biokinetics and Dosimetry in Radioiodine Therapy of Thyroid Cancer: Procedures and Results of a Prospective International Controlled Study of Ablation After rhTSH or Hormone Withdrawal
- Heribert Hänscheid, Michael Lassmann, Markus Luster, Stephen R. Thomas, Furio Pacini, Claudia Ceccarelli, Paul W. Ladenson, Richard L. Wahl, Martin Schlumberger, Marcel Ricard, Al Driedger, Richard T. Kloos, Steven I. Sherman, Bryan R. Haugen, Vincent Carriere, Carine Corone, and Christoph Reiners
JNM 2006 47: 648-654.
[Abstract]
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- Voxel-Based Mouse and Rat Models for Internal Dose Calculations
- Michael G. Stabin, Todd E. Peterson, George E. Holburn, and Mary A. Emmons
JNM 2006 47: 655-659.
[Abstract]
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- Potential Increased Tumor-Dose Delivery with Combined 131I-MIBG and 90Y-DOTATOC Treatment in Neuroendocrine Tumors: A Theoretic Model
- Mark T. Madsen, David L. Bushnell, Malik E. Juweid, Yusuf Menda, M. Sue O'Dorisio, Thomas O'Dorisio, and Ian M. Besse
JNM 2006 47: 660-667.
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- Tumor Targeting by an Aptamer
- Brian J. Hicke, Andrew W. Stephens, Ty Gould, Ying-Fon Chang, Cynthia K. Lynott, James Heil, Sandra Borkowski, Christoph-Stephan Hilger, Gary Cook, Stephen Warren, and Paul G. Schmidt
JNM 2006 47: 668-678.
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- Evaluation of D-Isomers of O-11C-Methyl Tyrosine and O-18F-Fluoromethyl Tyrosine as Tumor-Imaging Agents in Tumor-Bearing Mice: Comparison with L- and D-11C-Methionine
- Hideo Tsukada, Kengo Sato, Dai Fukumoto, Shingo Nishiyama, Norihiro Harada, and Takeharu Kakiuchi
JNM 2006 47: 679-688.
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- Assessment of Myocardial Metabolism in Diabetic Rats Using Small-Animal PET: A Feasibility Study
- Michael J. Welch, Jason S. Lewis, Joonyoung Kim, Terry L. Sharp, Carmen S. Dence, Robert J. Gropler, and Pilar Herrero
JNM 2006 47: 689-697.
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- Radiosynthesis and Preclinical Evaluation of 11C-ABP688 as a Probe for Imaging the Metabotropic Glutamate Receptor Subtype 5
- Simon M. Ametamey, Lea J. Kessler, Michael Honer, Matthias T. Wyss, Alfred Buck, Samuel Hintermann, Yves P. Auberson, Fabrizio Gasparini, and Pius A. Schubiger
JNM 2006 47: 698-705.
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- Preclinical Safety Evaluation of 18F-FHBG: A PET Reporter Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase (HSV1-tk) or Mutant HSV1-sr39tk's Expression
- Shahriar S. Yaghoubi, Marcelo A. Couto, Chang-Cheng Chen, Lathasree Polavaram, Guanggen Cui, Luyi Sen, and Sanjiv S. Gambhir
JNM 2006 47: 706-715.
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- Enhanced Efficacy of 90Y-Radiolabeled Anti-Lewis Y Humanized Monoclonal Antibody hu3S193 and Paclitaxel Combined-Modality Radioimmunotherapy in a Breast Cancer Model
- Marcus P. Kelly, Fook T. Lee, Fiona E. Smyth, Martin W. Brechbiel, and Andrew M. Scott
JNM 2006 47: 716-725.
[Abstract]
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