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Journal of Nuclear Medicine Vol. 47 No. 3 7a-8a
© 2006 by Society of Nuclear Medicine

This Month in JNM

Bodei and colleagues review current understanding of receptor-guided tumor targeting with radionuclides and introduce an article in this month's JNM that offers new data for clinical applications in radionuclide therapy.
Page 375

Lindner and colleagues use 11C-acetate PET to evaluate the effects of cardiac resynchronization therapy on myocardial oxygen consumption and cardiac efficiency in patients with severe heart failure and left bundle-branch block.
Page 378

Van Laere and colleagues investigate whether combined perfusion and dopamine transporter imaging can aid in early-stage differential diagnosis of parkinsonian disorders, including idiopathic Parkinson's disease, progressive supranuclear palsy, multiple system atrophy, dementia with Lewy bodies, and essential tremor.
Page 384

Pöpperl and colleagues compare extended analyses of 18F-FET uptake kinetics with standard tumor-to-background ratios in PET prediction of tumor grade in patients with pretreated gliomas.
Page 393
Figure 1

Kato and colleagues assess the relative usefulness of 123I-IMP SPECT and 18F-FDG PET for the detection of uveal malignant melanoma, the most common primary intraocular neoplasm in adults.
Page 404
Figure 2

Cher and colleagues use 18F-FMISO PET to assess hypoxia in newly diagnosed primary brain tumors and discuss its potential for directing patients toward targeted hypoxic therapies and monitoring treatment response.
Page 410

Guo and colleagues detail correlations between 18F-FDG uptake on PET and microvessel density determined with different endothelial cell antibodies in lung adenocarcinomas and describe the prognostic implications of these findings.
Page 419

Hashimoto and colleagues examine the characteristics of solid pulmonary nodules with low 18F-FDG uptake values and report on the ability of 18F-FDG PET to differentiate benign from malignant lung diseases both visually and semiquantitatively.
Page 426

Vegt and colleagues research the effects of infusion of low doses of the plasma expander succinylated gelatin on renal uptake of 111In-labeled octreotide and discuss possible toxicity-limiting applications in peptide receptor–mediated radiotherapy.
Page 432

Lee and colleagues characterize the mechanisms that mediate 123I-MIBG transport in pulmonary endothelial cells and investigate the effects of stimuli associated with pulmonary dysfunction.
Page 437
Figure 3

Yi and colleagues compare the diagnostic accuracies of helical dynamic CT and integrated PET/CT in patients with malignant solitary pulmonary nodules.
Page 443

Bunyaviroch and Coleman provide a comprehensive educational overview of the current practice and utility of PET in lung cancer.
Page 451

Brechtel and colleagues evaluate image coregistration results with 4 PET/CT examination protocols using contrast-enhanced single-phase or contrast-enhanced multiphase CT scans under different breathing conditions.
Page 470

Herrero and colleagues assess the relative abilities of 15O-water and 11C-acetate microPET in noninvasively quantifying myocardial blood flow in rats.
Page 477

Shichinohe and colleagues elucidate the mechanism of restored neurologic function through bone marrow stromal cell expression of the neuron-specific {gamma}-aminobutyric acid receptor transplanted into a mouse model of cerebral infarction.
Page 486
Figure 4

Zhang and colleagues describe the development of 18F-labeled bombesin analogs for PET imaging of gastrin-releasing peptide receptor expression in prostate cancer xenograft models.
Page 492

Cescato and colleagues apply novel immunocytochemical methods to measure somatostatin receptor internalization induced by a variety of somatostatin analogs, facilitating characterization of trafficking of somatostatin receptor subtypes in vitro at the protein level.
Page 502
Figure 5

Orlova and colleagues prepare the 99mTc-labeled affibody dimer His6-(ZHER2:4)2, assess its targeting properties in vitro and in vivo, and discuss possible applications in imaging of HER2 expression in primary breast carcinomas and extrahepatic metastases.
Page 512

Zoghbi and colleagues describe a radiometabolite generated by 18F-FECNT, a PET radioligand for dopamine transporters, and investigate whether this radiometabolite may contribute to errors in PET imaging in human and nonhuman primate brains.
Page 520

van Eerd and colleagues analyze the effects of several plasma expanders on the renal uptake of 111In-octreotide in rats and mice and discuss the potential for limiting toxicity in radiolabeled peptide therapy.
Page 528
Figure 6

Breitz and colleagues evaluate the pharmacokinetics and radiation-absorbed dose to all organs from the ß-emitting radiopharmaceutical 166Ho-DOTMP, which localizes to bone surfaces and shows promise for skeleton-targeted radiotherapy in multiple myeloma.
Page 534

Schmidt and colleagues explore the antiangiogenic effects of human angiostatin gene transfer on tumor growth and changes in perfusion or blood volume, using in vivo measurements with PET, immunohistochemistry, and gene expression analysis.
Page 543
ON THE COVER

PET/CT protocols for single-phase (top) and multiphase (bottom) examinations. At top, the purple spiral represents the whole body in portal-venous contrast enhancement. The scan includes the base of the skull to the proximal thigh, as in PET (blue cylinder). At bottom, the technical standard of the multiphase protocol requires 2 CT examinations: one covering the base of the skull to the lower borders of the kidneys during arterial contrast enhancement (red spiral) and another covering the base of the lungs to the proximal thighs in portal-venous phase enhancement (purple spiral). After reconstruction, low-dose CT (gray spiral) and PET are performed. The thickness of the spirals indicates the dose, and the width the collimation.
Figure 7

SEE PAGE 472

 


Related articles in JNM:

Receptor Radionuclide Therapy of Tumors: A Road from Basic Research to Clinical Applications
Lisa Bodei, Giovanni Paganelli, and Giuliano Mariani
JNM 2006 47: 375-377. [Full Text]  

Cardiac Efficiency and Oxygen Consumption Measured with 11C-Acetate PET After Long-Term Cardiac Resynchronization Therapy
Oliver Lindner, Jens Sörensen, Jürgen Vogt, Eva Fricke, Detlev Baller, Dieter Horstkotte, and Wolfgang Burchert
JNM 2006 47: 378-383. [Abstract] [Full Text]  

Dual-Tracer Dopamine Transporter and Perfusion SPECT in Differential Diagnosis of Parkinsonism Using Template-Based Discriminant Analysis
Koenraad Van Laere, Cindy Casteels, Liesbet De Ceuninck, Bert Vanbilloen, Alex Maes, Luc Mortelmans, Wim Vandenberghe, Alfons Verbruggen, and René Dom
JNM 2006 47: 384-392. [Abstract] [Full Text]  

Analysis of 18F-FET PET for Grading of Recurrent Gliomas: Is Evaluation of Uptake Kinetics Superior to Standard Methods?
Gabriele Pöpperl, Friedrich W. Kreth, Jochen Herms, Walter Koch, Jan H. Mehrkens, Franz J. Gildehaus, Hans A. Kretzschmar, Jörg C. Tonn, and Klaus Tatsch
JNM 2006 47: 393-403. [Abstract] [Full Text]  

Low Efficacy of 18F-FDG PET for Detection of Uveal Malignant Melanoma Compared with 123I-IMP SPECT
Katsuhiko Kato, Toshinobu Kubota, Mitsuru Ikeda, Masanori Tadokoro, Shinji Abe, Satoshi Nakano, Masanari Nishino, Hidetoshi Kobayashi, and Takeo Ishigaki
JNM 2006 47: 404-409. [Abstract] [Full Text]  

Correlation of Hypoxic Cell Fraction and Angiogenesis with Glucose Metabolic Rate in Gliomas Using 18F-Fluoromisonidazole, 18F-FDG PET, and Immunohistochemical Studies
Lawrence M. Cher, Carmel Murone, Nathan Lawrentschuk, Shanker Ramdave, Anthony Papenfuss, Anthony Hannah, Graeme J. O'Keefe, John I. Sachinidis, Salvatore U. Berlangieri, Gavin Fabinyi, and Andrew M. Scott
JNM 2006 47: 410-418. [Abstract] [Full Text]  

Microvessel Density: Correlation with 18F-FDG Uptake and Prognostic Impact in Lung Adenocarcinomas
JianFei Guo, Kotaro Higashi, Yoshimichi Ueda, Manabu Oguchi, Tsutomu Takegami, Hirohisa Toga, Tsutomu Sakuma, Hajime Yokota, Shogo Katsuda, Hisao Tonami, and Itaru Yamamoto
JNM 2006 47: 419-425. [Abstract] [Full Text]  

Accuracy of PET for Diagnosis of Solid Pulmonary Lesions with 18F-FDG Uptake Below the Standardized Uptake Value of 2.5
Yaichiro Hashimoto, Tetsuya Tsujikawa, Chisato Kondo, Masako Maki, Mitsuru Momose, Atsushi Nagai, Takamasa Ohnuki, Toshio Nishikawa, and Kiyoko Kusakabe
JNM 2006 47: 426-431. [Abstract] [Full Text]  

Renal Uptake of Radiolabeled Octreotide in Human Subjects Is Efficiently Inhibited by Succinylated Gelatin
Erik Vegt, Jack F.M. Wetzels, Frans G.M. Russel, Rosalinde Masereeuw, Otto C. Boerman, Juliette E. van Eerd, Frans H.M. Corstens, and Wim J.G. Oyen
JNM 2006 47: 432-436. [Abstract] [Full Text]  

Characteristics and Regulation of 123I-MIBG Transport in Cultured Pulmonary Endothelial Cells
Kyung-Han Lee, Bong-Ho Ko, Jin-Young Paik, Kyung-Ho Jung, Jun-Sang Bae, Joon-Young Choi, Yearn Seong Choe, and Byung-Tae Kim
JNM 2006 47: 437-442. [Abstract] [Full Text]  

Tissue Characterization of Solitary Pulmonary Nodule: Comparative Study Between Helical Dynamic CT and Integrated PET/CT
Chin A Yi, Kyung Soo Lee, Byung-Tae Kim, Joon Young Choi, O. Jung Kwon, Hojoong Kim, Young Mog Shim, and Myung Jin Chung
JNM 2006 47: 443-450. [Abstract] [Full Text]  

PET Evaluation of Lung Cancer
Tira Bunyaviroch and R. Edward Coleman
JNM 2006 47: 451-469. [Full Text]  

Optimized Contrast-Enhanced CT Protocols for Diagnostic Whole-Body 18F-FDG PET/CT: Technical Aspects of Single-Phase Versus Multiphase CT Imaging
Klaus Brechtel, Magnus Klein, Monika Vogel, Marc Mueller, Philip Aschoff, Thomas Beyer, Susanna M. Eschmann, Roland Bares, Claus D. Claussen, and Anna C. Pfannenberg
JNM 2006 47: 470-476. [Abstract] [Full Text]  

Assessment of Myocardial Blood Flow Using 15O-Water and 1-11C-Acetate in Rats with Small-Animal PET
Pilar Herrero, Joonyoung Kim, Terry L. Sharp, John A. Engelbach, Jason S. Lewis, Robert J. Gropler, and Michael J. Welch
JNM 2006 47: 477-485. [Abstract] [Full Text]  

Improved Expression of {gamma}-Aminobutyric Acid Receptor in Mice with Cerebral Infarct and Transplanted Bone Marrow Stromal Cells: An Autoradiographic and Histologic Analysis
Hideo Shichinohe, Satoshi Kuroda, Shunsuke Yano, Takako Ohnishi, Hiroshi Tamagami, Kazutoshi Hida, and Yoshinobu Iwasaki
JNM 2006 47: 486-491. [Abstract] [Full Text]  

18F-Labeled Bombesin Analogs for Targeting GRP Receptor-Expressing Prostate Cancer
Xianzhong Zhang, Weibo Cai, Feng Cao, Eduard Schreibmann, Yun Wu, Joseph C. Wu, Lei Xing, and Xiaoyuan Chen
JNM 2006 47: 492-501. [Abstract] [Full Text]  

Internalization of sst2, sst3, and sst5 Receptors: Effects of Somatostatin Agonists and Antagonists
Renzo Cescato, Stefan Schulz, Beatrice Waser, Véronique Eltschinger, Jean E. Rivier, Hans-Jürgen Wester, Michael Culler, Mihaela Ginj, Qisheng Liu, Agnes Schonbrunn, and Jean Claude Reubi
JNM 2006 47: 502-511. [Abstract] [Full Text]  

Comparative In Vivo Evaluation of Technetium and Iodine Labels on an Anti-HER2 Affibody for Single-Photon Imaging of HER2 Expression in Tumors
Anna Orlova, Fredrik Y. Nilsson, Maria Wikman, Charles Widström, Stefan Ståhl, Jörgen Carlsson, and Vladimir Tolmachev
JNM 2006 47: 512-519. [Abstract] [Full Text]  

PET Imaging of the Dopamine Transporter with 18F-FECNT: A Polar Radiometabolite Confounds Brain Radioligand Measurements
Sami S. Zoghbi, H. Umesha Shetty, Masanori Ichise, Masahiro Fujita, Masao Imaizumi, Jeih-San Liow, Jay Shah, John L. Musachio, Victor W. Pike, and Robert B. Innis
JNM 2006 47: 520-527. [Abstract] [Full Text]  

Gelatin-Based Plasma Expander Effectively Reduces Renal Uptake of 111In-Octreotide in Mice and Rats
Julliëtte E.M. van Eerd, Erik Vegt, Jack F.M. Wetzels, Frans G.M. Russel, Rosalinde Masereeuw, Frans H.M. Corstens, Wim J.G. Oyen, and Otto C. Boerman
JNM 2006 47: 528-533. [Abstract] [Full Text]  

166Ho-DOTMP Radiation-Absorbed Dose Estimation for Skeletal Targeted Radiotherapy
Hazel B. Breitz, Richard E. Wendt, III, Michael S. Stabin, Sui Shen, William D. Erwin, Joseph G. Rajendran, Janet F. Eary, Lawrence Durack, Ebrahim Delpassand, William Martin, and Ruby F. Meredith
JNM 2006 47: 534-542. [Abstract] [Full Text]  

Angiostatin Overexpression in Morris Hepatoma Results in Decreased Tumor Growth but Increased Perfusion and Vascularization
Kerstin Schmidt, Johannes Hoffend, Annette Altmann, Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Britta Engelhardt, Dirk Koczan, Jörg Peter, Thomas J. Dengler, Walter Mier, Michael Eisenhut, Uwe Haberkorn, and Ralf Kinscherf
JNM 2006 47: 543-551. [Abstract] [Full Text]  




This Article
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