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Journal of Nuclear Medicine Vol. 47 No. 2 7a-8a
© 2006 by Society of Nuclear Medicine

This Month in JNM

Uren reviews the relatively brief history and current clinical significance of the sentinel lymph node biopsy technique and looks to the literature for answers to key questions about the efficacy and safety of this increasingly important approach.
Page 191

Reilly surveys the development of pretargeting strategies using monoclonal antibodies and, previewing an article in this issue of JNM, outlines the promise and challenges of pretargeting using bispecific antibodies and radiolabeled haptens.
Page 196
Figure 1

Meyer and colleagues assess the application of voxelwise graphical analysis to the generation of high-quality parametric images of total volume of distribution of the novel PET tracer 18F-CPFPX in imaging of cerebral adenosine receptors.
Page 200

Kim and colleagues research the reproducibility and reliability of 11C-DASB parametric imaging of binding potential and relative blood flow for PET studies of serotonin transporters in humans.
Page 208

Ciarmiello and colleagues report on findings, including PET data, indicating that white-matter volume loss may precede gray-matter atrophy long before onset of clinical symptoms of Huntington's disease and that this loss may be associated with neuronal dysfunction in early disease.
Page 215

Ezziddin and colleagues explore predisposing factors for uptake of both 111In-pentetreotide and 123I/131I-MIBG in scintigraphy of patients with metastatic gastroenteropancreatic endocrine tumors, with special reference to new World Health Organization tumor classifications.
Page 223

Rossi and colleagues present findings from an observational multicenter trial of a standardized sentinel lymph node biopsy protocol in patients with primary cutaneous melanoma.
Page 234

Fang and colleagues investigate correlations between serum interleukin-2 and tumor necrosis factor-{alpha} levels and response to 89SrCl2 as palliative therapy in patients with painful bone metastases.
Page 242

Kraeber-Bodéré and colleagues report on the results of a phase I study of the safety, targeting, and antitumor efficacy of pretargeted radioimmunotherapy using an anti-carcinoembryonic antigen bispecific antibody and a radiolabeled hapten in patients with nonmedullary or medullary thyroid carcinoma.
Page 247
Figure 2

Pauleit and colleagues compare the diagnostic capabilities of 18F-FET and 18F-FDG PET in patients with squamous cell carcinoma of the head and neck, including the ability to differentiate between tumor and inflammation.
Page 256

Kwee and colleagues assess 18F-fluorocholine uptake in malignant and benign areas of the prostate at 2 time points to determine the suitability of delayed or dual-phase 18F-fluorocholine PET for localizing malignancy.
Page 262

Padmanabhan and colleagues evaluate radionuclide and optical methods to measure changes in human telomerase reverse transcriptase gene expression in tumor cells before and after 5-fluorouracil treatment.
Page 270
Figure 3

Zenz and colleagues study the incidence and clinical picture of bone marrow transplantation nephropathy in patients receiving a radiolabeled anti-CD66 antibody before allogeneic stem cell transplantation.
Page 278

Even-Sapir and colleagues report on the comparative abilities of 99mTc-MDP planar bone scintigraphy, SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT in the detection of bone metastases in patients with high-risk prostate cancer.
Page 287

Allen-Auerbach and colleagues investigate the incidence of missed pulmonary micronodules on PET/CT studies acquired during shallow breathing and discuss the implications of their findings for comprehensive cancer staging.
Page 298

Heiss and Herholz present an in-depth review of brain receptor imaging and highlight ligands and receptors that are already in clinical use and are likely to influence new drug development and enhance highly specific neurologic imaging.
Page 302
Figure 4

Slifstein and colleagues perform whole-body radiation dosimetry of 11C-raclopride in healthy humans to derive the maximum allowable single-study dose under U.S. federal regulations and compare this to the dose range currently used in PET research studies.
Page 313

Garcia and colleagues describe a novel system developed to assist physicians in detecting renal obstruction in patients undergoing pre- and postfurosemide 99mTc-MAG3 scanning.
Page 320

Kim and colleagues report on a factor analysis technique for extracting blood input function and myocardial time–activity curve from dynamic small-animal PET images of the rodent heart as a method for overcoming imaging problems caused by cardiac motion.
Page 330

Maskali and colleagues assess a novel gated SPECT imaging technique for predicting and quantifying variable left ventricular remodeling in a rat infarct model.
Page 337
Figure 5

Tipre and colleagues explore in vivo inhibition of defluorination of 18F-FCWAY in a rat model to improve use of the tracer in PET assessment of brain regional 5-HT1A receptor densities.
Page 345
Figure 6

Gunn and colleagues investigate whether somatostatin receptor (sst) gene expression is upregulated in vitro by exposure of sst-expressing cells to low- or high-dose octreotide therapy over varying times.
Page 354

Liu and colleagues detail initial studies of the mechanism of intracellular antisense targeting through measurements of in situ transcription, immunofluorescence, reverse transcription polymerase chain reaction, 32P-labeled uridine-5'-triphosphate incorporation, accumulations of 99mTc-labeled DNAs, and messenger RNA transcription.
Page 360
ON THE COVER

In this illustration of the possible effect of different numbers of radiotracer injections (X) on the outcome of lymphoscintigraphy, arrows represent lymphatic flow. A single injection (left) might enter only central lymphatic vessels, missing those potentially containing malignant cells. Moreover, the large volume of tracer used might cause nonsentinel nodes to be detected. Multiple injections (right) might enter peripheral lymphatic vessels and thus detect sentinel nodes containing metastatic melanoma cells. Moreover, the small volume of tracer used might help to avoid detection of second-tier nodes.
Figure 7

 


Related articles in JNM:

Sentinel Lymph Node Biopsy in Melanoma
Roger F. Uren
JNM 2006 47: 191-195. [Full Text]  

Radioimmunotherapy of Solid Tumors: The Promise of Pretargeting Strategies Using Bispecific Antibodies and Radiolabeled Haptens
Raymond M. Reilly
JNM 2006 47: 196-199. [Full Text]  

18F-CPFPX PET: On the Generation of Parametric Images and the Effect of Scan Duration
Philipp T. Meyer, David Elmenhorst, Andreas Matusch, Oliver Winz, Karl Zilles, and Andreas Bauer
JNM 2006 47: 200-207. [Abstract] [Full Text]  

PET Imaging of Serotonin Transporters with [11C]DASB: Test–Retest Reproducibility Using a Multilinear Reference Tissue Parametric Imaging Method
Jae Seung Kim, Masanori Ichise, Janet Sangare, and Robert B. Innis
JNM 2006 47: 208-214. [Abstract] [Full Text]  

Brain White-Matter Volume Loss and Glucose Hypometabolism Precede the Clinical Symptoms of Huntington's Disease
Andrea Ciarmiello, Milena Cannella, Secondo Lastoria, Maria Simonelli, Luigi Frati, David C. Rubinsztein, and Ferdinando Squitieri
JNM 2006 47: 215-222. [Abstract] [Full Text]  

Factors Predicting Tracer Uptake in Somatostatin Receptor and MIBG Scintigraphy of Metastatic Gastroenteropancreatic Neuroendocrine Tumors
Samer Ezziddin, Timur Logvinski, Charlotte Yong-Hing, Hojjat Ahmadzadehfar, Hans-Peter Fischer, Holger Palmedo, Jan Bucerius, Michael J. Reinhardt, and Hans-Jürgen Biersack
JNM 2006 47: 223-233. [Abstract] [Full Text]  

The Impact of Lymphoscintigraphy Technique on the Outcome of Sentinel Node Biopsy in 1,313 Patients with Cutaneous Melanoma: An Italian Multicentric Study (SOLISM–IMI)
Carlo Riccardo Rossi, Gian Luca De Salvo, Giuseppe Trifirò, Simone Mocellin, Giorgio Landi, Giuseppe Macripò, Paolo Carcoforo, Giuseppe Ricotti, Giuseppe Giudice, Franco Picciotto, Davide Donner, Franco Di Filippo, Maria Cristina Montesco, Dario Casara, Mauro Schiavon, Mirto Foletto, Federica Baldini, and Alessandro Testori
JNM 2006 47: 234-241. [Abstract] [Full Text]  

Serum Concentrations of IL-2 and TNF-{alpha} in Patients with Painful Bone Metastases: Correlation with Responses to 89SrCl2 Therapy
Na Fang, Yong Li, Yan-song Xu, Duo Ma, Peng Fu, Hui-qi Gao, Feng-tong Gao, Hai-shan Yang, and Zhi-jie Yang
JNM 2006 47: 242-246. [Abstract] [Full Text]  

Targeting, Toxicity, and Efficacy of 2-Step, Pretargeted Radioimmunotherapy Using a Chimeric Bispecific Antibody and 131I-Labeled Bivalent Hapten in a Phase I Optimization Clinical Trial
Françoise Kraeber-Bodéré, Caroline Rousseau, Caroline Bodet-Milin, Ludovic Ferrer, Alain Faivre-Chauvet, Loïc Campion, Jean-Philippe Vuillez, Anne Devillers, Chien-Hsing Chang, David M. Goldenberg, Jean-François Chatal, and Jacques Barbet
JNM 2006 47: 247-255. [Abstract] [Full Text]  

18F-FET PET Compared with 18F-FDG PET and CT in Patients with Head and Neck Cancer
Dirk Pauleit, Andre Zimmermann, Gabriele Stoffels, Dagmar Bauer, Jörn Risse, Michael O. Flüss, Kurt Hamacher, Heinz H. Coenen, and Karl-Josef Langen
JNM 2006 47: 256-261. [Abstract] [Full Text]  

Localization of Primary Prostate Cancer with Dual-Phase 18F-Fluorocholine PET
Sandi A. Kwee, Hai Wei, Isabell Sesterhenn, David Yun, and Marc N. Coel
JNM 2006 47: 262-269. [Abstract] [Full Text]  

Visualization of Telomerase Reverse Transcriptase (hTERT) Promoter Activity Using a Trimodality Fusion Reporter Construct
Parasuraman Padmanabhan, Jesse Otero, Pritha Ray, Ramasamy Paulmurugan, Andrew R. Hoffman, Sanjiv S. Gambhir, Sandip Biswal, and Gary A. Ulaner
JNM 2006 47: 270-277. [Abstract] [Full Text]  

Bone Marrow Transplantation Nephropathy after an Intensified Conditioning Regimen with Radioimmunotherapy and Allogeneic Stem Cell Transplantation
Thorsten Zenz, Richard F. Schlenk, Gerhard Glatting, Bernd Neumaier, Norbert Blumstein, Inga Buchmann, Stephanie von Harsdorf, Mark Ringhoffer, Markus Wiesneth, Frieder Keller, Jörg Kotzerke, Erwin Röttinger, Stephan Stilgenbauer, Hartmut Döhner, Sven N. Reske, and Donald Bunjes
JNM 2006 47: 278-286. [Abstract] [Full Text]  

The Detection of Bone Metastases in Patients with High-Risk Prostate Cancer: 99mTc-MDP Planar Bone Scintigraphy, Single- and Multi-Field-of-View SPECT, 18F-Fluoride PET, and 18F-Fluoride PET/CT
Einat Even-Sapir, Ur Metser, Eyal Mishani, Gennady Lievshitz, Hedva Lerman, and Ilan Leibovitch
JNM 2006 47: 287-297. [Abstract] [Full Text]  

Standard PET/CT of the Chest During Shallow Breathing Is Inadequate for Comprehensive Staging of Lung Cancer
Martin Allen-Auerbach, Kristen Yeom, John Park, Michael Phelps, and Johannes Czernin
JNM 2006 47: 298-301. [Abstract] [Full Text]  

Brain Receptor Imaging
Wolf-Dieter Heiss and Karl Herholz
JNM 2006 47: 302-312. [Abstract] [Full Text]  

Biodistribution and Radiation Dosimetry of the Dopamine D2 Ligand 11C-Raclopride Determined from Human Whole-Body PET
Mark Slifstein, Dah-Ren Hwang, Diana Martinez, Jesper Ekelund, Yiyun Huang, Elizabeth Hackett, Anissa Abi-Dargham, and Marc Laruelle
JNM 2006 47: 313-319. [Abstract] [Full Text]  

RENEX: An Expert System for the Interpretation of 99mTc-MAG3 Scans to Detect Renal Obstruction
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JNM 2006 47: 320-329. [Abstract] [Full Text]  

Minimally Invasive Method of Determining Blood Input Function from PET Images in Rodents
Joonyoung Kim, Pilar Herrero, Terry Sharp, Richard Laforest, Douglas J. Rowland, Yuan-Chuan Tai, Jason S. Lewis, and Michael J. Welch
JNM 2006 47: 330-336. [Abstract] [Full Text]  

Initial Infarct Size Predicts Subsequent Cardiac Remodeling in the Rat Infarct Model: An In Vivo Serial Pinhole Gated SPECT Study
Fatiha Maskali, Philippe R. Franken, Sylvain Poussier, Nguyen Tran, Chris Vanhove, Henri Boutley, Hervé Le Gall, Gilles Karcher, Faïez Zannad, Patrick Lacolley, and Pierre Y. Marie
JNM 2006 47: 337-344. [Abstract] [Full Text]  

PET Imaging of Brain 5-HT1A Receptors in Rat In Vivo with 18F-FCWAY and Improvement by Successful Inhibition of Radioligand Defluorination with Miconazole
Dnyanesh N. Tipre, Sami S. Zoghbi, Jeih-San Liow, Michael V. Green, Jurgen Seidel, Masanori Ichise, Robert B. Innis, and Victor W. Pike
JNM 2006 47: 345-353. [Abstract] [Full Text]  

In Vitro Modeling of the Clinical Interactions Between Octreotide and 111In-Pentetreotide: Is There Evidence of Somatostatin Receptor Downregulation?
Susan H. Gunn, Joshua E. Schwimer, Mary Cox, Catherine T. Anthony, Mary Sue O'Dorisio, and Eugene A. Woltering
JNM 2006 47: 354-359. [Abstract] [Full Text]  

Initial Mechanistic Studies of Antisense Targeting in Cells
Xinrong Liu, Kayoko Nakamura, Yi Wang, Yee Wang, Guozheng Liu, Jiang He, Hongliu Ding, Peiyuan Lu, Mary Rusckowski, Atsushi Kubo, and Donald J. Hnatowich
JNM 2006 47: 360-368. [Abstract] [Full Text]  




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