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FIGURE 3. Scatter plot of fGM (
), fWM (
), and fCSF (
) volumes vs. age in healthy subjects (red shapes), affected subjects (white shapes), and presymptomatic population (blue shapes). Affected subjects (n = 47) have significantly smaller fGM and fWM volumes than do healthy subjects (46.7 ± 4.0 mL vs. 52.4 ± 2.1 mL, P < 0.0001, and 30.0 ± 3.5 mL vs. 37.7 ± 2.2 mL, P < 0.0001, respectively), with corresponding increase in fCSF (23.1 ± 5.1 mL vs. 10.0 ± 2.4 mL, P < 0.0001). Presymptomatic subjects (n = 24) have significantly smaller fGM and fWM volumes than do healthy subjects (n = 54) (51.2 ± 2.2 mL vs. 52.4 ± 2.1 mL, P = 0.0506, and 35.3 ± 2.5 mL vs. 37.7 ± 2.2 mL, P < 0.0001, respectively), with corresponding increase in fCSF volume (13.5 ± 3.5 mL vs. 10.0 ± 2.4 mL, P < 0.0001).
