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FIGURE 4. Representative parametric images of 11C-DTBZ DVR and corresponding 11C-HED RI polar maps. Parametric images of 11C-DTBZ DVR are all scaled to common maximum of 3.5. DVR is related to binding potential (BP) by equation BP = DVR – 1 and is unitless. Polar maps of 11C-HED RI values are all scaled to common maximum of 0.090 mL of blood per min per mL of tissue. NC 5 images show high striatal binding of 11C-DTBZ and high, uniform cardiac retention of 11C-HED in healthy control subject. MSA 1 images show low striatal 11C-DTBZ binding and extensive severe cardiac denervation, as seen in 2 patients with MSA. MSA 4 images show low striatal 11C-DTBZ binding and normal uniform cardiac 11C-HED retention, as seen in 4 patients with MSA. MSA 9 images show normal striatal 11C-DTBZ binding and normal uniform cardiac 11C-HED retention, as seen in 4 patients with MSA. IPD 3 images show low striatal 11C-DTBZ binding and extensive severe cardiac denervation, as seen in 4 patients with IPD. IPD 7 images show low 11C-DTBZ binding in posterior putamen (with uncharacteristically well-preserved 11C-DTBZ binding in caudate nucleus) and normal uniform cardiac innervation, as seen in 5 patients with IPD. PSP 3 images show low striatal 11C-DTBZ binding and nonuniform cardiac denervation, as seen in 2 patients with PSP. PSP 8 images show low striatal 11C-DTBZ binding and normal uniform cardiac denervation, as seen in 5 patients with PSP.
