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Journal of Nuclear Medicine Vol. 47 No. 10 9a-10a
© 2006 by Society of Nuclear Medicine

This Month in JNM

Late effects of radioablation: Reiners and colleagues review recent literature on the risk of secondary cancers after radiation treatment and preview an article in this issue of JNM on potential sequelae to radioiodine ablation in children near Chernobyl.
Page 1563

Optimal patient selection for CRT: Ypenburg and colleagues assess whether the extent of myocardial viability on 18F-FDG SPECT at intervention can accurately forecast the success of cardiac resynchronization therapy in patients with heart failure.
Page 1565

Enhanced imaging of granulomas: Nishiyama and colleagues compare tracer uptake on 18F-FDG PET and 67Ga whole-body planar and thoracic imaging in the evaluation of pulmonary and extrapulmonary involvement in patients with sarcoidosis.
Page 1571
Figure 1

Strategic approach to heel pain: Frater and colleagues devise a set of scintigraphic criteria based on blood-pool abnormalities to predict the success of steroid injection therapies in patients with plantar fasciitis.
Page 1577

Noninvasive misery perfusion evaluation: Kobayashi and colleagues describe a novel technique for measuring asymmetric increases in oxygen extraction fraction in H215O PET studies in cerebrovascular disease and point to advantages in technical simplicity and decreased patient discomfort.
Page 1581

Reevaluating 131I doses in the elderly: Tuttle and colleagues look at age-associated differences in maximum tolerated activity in fixed-dose 131I therapy for metastatic thyroid cancer.
Page 1587

PET and bone marrow cellularity: Agool and colleagues investigate the feasibility of using 18F-FLT PET to visualize and quantify proliferative activity in the bone marrow compartment to differentiate among various hematologic disorders.
Page 1592
Figure 2

Identifying somatostatin receptor subtypes: van Essen and colleagues describe the effects of 177Lu-octreotate therapy in patients with metastasized or inoperable paragangliomas, meningiomas, small cell lung carcinomas, and melanomas.
Page 1599
Figure 3

Brain PET and operable NSCLC: Posther and colleagues ask whether 18F-FDG PET provides useful information in patients whose suspected or proven non–small cell lung cancer is considered resectable on the basis of conventional imaging approaches.
Page 1607

Kinetics of 18F-FLT brain imaging: Muzi and colleagues investigate compartmental modeling of tracer transport and retention in 18F-FLT studies to assess cellular proliferation in patients with gliomas.
Page 1612
Figure 4

PET and celiac disease progression: Hadithi and colleagues compare 18F-FDG PET and CT in the detection of enteropathy-associated T-cell lymphoma in patients with refractory celiac disease.
Page 1622
Figure 5

PET/CT vs. CT in thymic tumors: Sung and colleagues assess the utility of 18F-FDG PET/CT in distinguishing subgroups of thymic epithelial tumors and for staging extent of disease.
Page 1628

PET/CT in SNS imaging: Franzius and colleagues evaluate the feasibility of whole-body 11C-HED PET/low-dose CT for examination of tumors of the sympathetic nervous system and compare the results with those from 123I-MIBG scintigraphy and SPECT/CT.
Page 1635

Effective PET/CT dose reduction: Rodríguez-Vigil and colleagues compare contrast-enhanced full-dose PET/CT and unenhanced low-dose 18F-FDG PET/CT in lesion detection and initial staging of Hodgkin's disease and non-Hodgkin's lymphoma.
Page 1643
Figure 6

Novel tracer for prostate imaging: Peng and colleagues investigate the use of 64CuCl2 as a probe in PET localization of human prostate cancer xenografts in mice and discuss the implications for clinical use in locally recurrent tumors.
Page 1649
Figure 7

Radiologic threat preparedness: Barnett and colleagues provide an educational overview of radiologic and nuclear terrorism as public health threats and discuss appropriate preparedness and response perspectives for nuclear medicine professionals.
Page 1653

Optimizing clinical SPECT: Xiao and colleagues compare the performances of Monte Carlo–based and window-based scatter correction in 99mTc SPECT cardiac imaging.
Page 1662

Molecular targeting of mRNA: Watanabe and colleagues investigate the therapeutic effect of Auger electrons emitted by 111In-labeled phosphorothioate antisense oligonucleotides on human neuroblastoma cells.
Page 1670

ImmunoPET investigations: McBride and colleagues continue their work with bispecific antibody pretargeting for tumor imaging, here reporting on a radioiodination procedure to assess PET imaging with 124I.
Page 1678
Figure 8

Tracing dependence: Horti and colleagues evaluate an 11C-labeled analog of a cerebral cannabinoid receptor antagonist as a potential radioligand for PET imaging of addiction and related neuropsychiatric disorders.
Page 1689

Novel serotonin agent: Saigal and colleagues report on the radiosynthesis and in vitro and in vivo binding characteristics of 18F-mefway, a more stable serotonin 5-HT1A agent for use in PET imaging in disorders of the central nervous system.
Page 1697

99mTc-labeled fibronectin antibodies: Berndorff and colleagues detail the synthesis and 99mTc labeling of compounds to target the angiogenesis-associated extracellular matrix protein ED-B fibronectin for scintigraphic molecular imaging of solid tumors.
Page 1707
Figure 9

DNA synthesis imaging: Toyohara and colleagues describe the production of a novel thymidine analog for simplified 11C-PET imaging of DNA synthesis in tumor cell proliferation.
Page 1717

Long-term follow-up recommended: Travis and Stabin review treatment data from children in the Chernobyl area who underwent radioiodine ablation and estimate the increased risk of cancers––including breast cancer––in this population.
Page 1723
ON THE COVER

Because serotonin 5-HT1A receptors have been implicated in disorders of the central nervous system, efforts are under way to develop fluorinated PET radiotracers that are stable to metabolism, easily synthesized, and highly selective for 5-HT1A receptors. 18F-Mefway has shown value as such a radiotracer and is, in addition, sensitive to being displaced by serotonin, suggesting potential as a PET agent for measuring changes in serotonin concentration in the living brain.
Figure 10

SEE PAGE 1703

 


Related articles in JNM:

A Perspective on Post-Chernobyl Radioablation in Young Females
Christoph Reiners, Michael Lassmann, and Heribert Hänscheid
JNM 2006 47: 1563-1564. [Full Text]  

Extent of Viability to Predict Response to Cardiac Resynchronization Therapy in Ischemic Heart Failure Patients
Claudia Ypenburg, Martin J. Schalij, Gabe B. Bleeker, Paul Steendijk, Eric Boersma, Petra Dibbets-Schneider, Marcel P. Stokkel, Ernst E. van der Wall, and Jeroen J. Bax
JNM 2006 47: 1565-1570. [Abstract] [Full Text]  

Comparative Evaluation of 18F-FDG PET and 67Ga Scintigraphy in Patients with Sarcoidosis
Yoshihiro Nishiyama, Yuka Yamamoto, Kotaro Fukunaga, Hiroyuki Takinami, Yasuyoshi Iwado, Katashi Satoh, and Motoomi Ohkawa
JNM 2006 47: 1571-1576. [Abstract] [Full Text]  

Bone Scintigraphy Predicts Outcome of Steroid Injection for Plantar Fasciitis
Clayton Frater, Dzung Vu, Hans Van der Wall, Chandima Perera, Paul Halasz, Louise Emmett, and Ignac Fogelman
JNM 2006 47: 1577-1580. [Abstract] [Full Text]  

Diagnosis of Misery Perfusion Using Noninvasive 15O-Gas PET
Masato Kobayashi, Hidehiko Okazawa, Tatsuro Tsuchida, Keiichi Kawai, Yasuhisa Fujibayashi, and Yoshiharu Yonekura
JNM 2006 47: 1581-1586. [Abstract] [Full Text]  

Empiric Radioactive Iodine Dosing Regimens Frequently Exceed Maximum Tolerated Activity Levels in Elderly Patients with Thyroid Cancer
R. Michael Tuttle, Rebecca Leboeuf, Richard J. Robbins, Rebecca Qualey, Keith Pentlow, Steven M. Larson, and Chee Y. Chan
JNM 2006 47: 1587-1591. [Abstract] [Full Text]  

18F-FLT PET in Hematologic Disorders: A Novel Technique to Analyze the Bone Marrow Compartment
Ali Agool, Bart W. Schot, Pieter L. Jager, and Edo Vellenga
JNM 2006 47: 1592-1598. [Abstract] [Full Text]  

Effects of Therapy with [177Lu-DOTA0, Tyr3]Octreotate in Patients with Paraganglioma, Meningioma, Small Cell Lung Carcinoma, and Melanoma
Martijn van Essen, Eric P. Krenning, Peter P. Kooij, Willem H. Bakker, Richard A. Feelders, Wouter W. de Herder, John G. Wolbers, and Dik J. Kwekkeboom
JNM 2006 47: 1599-1606. [Abstract] [Full Text]  

Yield of Brain 18F-FDG PET in Evaluating Patients with Potentially Operable Non–Small Cell Lung Cancer
Katherine E. Posther, Linda M. McCall, David H. Harpole, Jr., Carolyn E. Reed, Joe B. Putnam, Jr., Valerie W. Rusch, and Barry A. Siegel
JNM 2006 47: 1607-1611. [Abstract] [Full Text]  

Kinetic Analysis of 3'-Deoxy-3'-18F-Fluorothymidine in Patients with Gliomas
Mark Muzi, Alexander M. Spence, Finbarr O'Sullivan, David A. Mankoff, Joanne M. Wells, John R. Grierson, Jeanne M. Link, and Kenneth A. Krohn
JNM 2006 47: 1612-1621. [Abstract] [Full Text]  

18F-FDG PET Versus CT for the Detection of Enteropathy-Associated T-Cell Lymphoma in Refractory Celiac Disease
Muhammed Hadithi, Maarten Mallant, Joost Oudejans, Jan-Hein T.M. van Waesberghe, Chris J. Mulder, and Emile F.I. Comans
JNM 2006 47: 1622-1627. [Abstract] [Full Text]  

18F-FDG PET/CT of Thymic Epithelial Tumors: Usefulness for Distinguishing and Staging Tumor Subgroups
Yon Mi Sung, Kyung Soo Lee, Byung-Tae Kim, Joon Young Choi, Young Mog Shim, and Chin A. Yi
JNM 2006 47: 1628-1634. [Abstract] [Full Text]  

Whole-Body PET/CT with 11C-Meta-Hydroxyephedrine in Tumors of the Sympathetic Nervous System: Feasibility Study and Comparison with 123I-MIBG SPECT/CT
Christiane Franzius, Klaudia Hermann, Matthias Weckesser, Klaus Kopka, Kai Uwe Juergens, Josef Vormoor, and Otmar Schober
JNM 2006 47: 1635-1642. [Abstract] [Full Text]  

PET/CT in Lymphoma: Prospective Study of Enhanced Full-Dose PET/CT Versus Unenhanced Low-Dose PET/CT
Beatriz Rodríguez-Vigil, Nieves Gómez-León, Inmaculada Pinilla, Dolores Hernández-Maraver, Juan Coya, Luis Martín-Curto, and Rosario Madero
JNM 2006 47: 1643-1648. [Abstract] [Full Text]  

PET of Human Prostate Cancer Xenografts in Mice with Increased Uptake of 64CuCl2
Fangyu Peng, Xin Lu, James Janisse, Otto Muzik, and Anthony F. Shields
JNM 2006 47: 1649-1652. [Abstract] [Full Text]  

Understanding Radiologic and Nuclear Terrorism as Public Health Threats: Preparedness and Response Perspectives
Daniel J. Barnett, Cindy L. Parker, David W. Blodgett, Rachel K. Wierzba, and Jonathan M. Links
JNM 2006 47: 1653-1661. [Abstract] [Full Text]  

Evaluation of 3D Monte Carlo–Based Scatter Correction for 99mTc Cardiac Perfusion SPECT
Jianbin Xiao, Tim C. de Wit, Steven G. Staelens, and Freek J. Beekman
JNM 2006 47: 1662-1669. [Abstract] [Full Text]  

Molecular Therapy of Human Neuroblastoma Cells Using Auger Electrons of 111In-Labeled N-myc Antisense Oligonucleotides
Naoyuki Watanabe, Hiroaki Sawai, Izumi Ogihara-Umeda, Shuji Tanada, E. Edmund Kim, Yoshiharu Yonekura, and Yasuhito Sasaki
JNM 2006 47: 1670-1677. [Abstract] [Full Text]  

Bispecific Antibody Pretargeting PET (ImmunoPET) with an 124I-Labeled Hapten-Peptide
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JNM 2006 47: 1678-1688. [Abstract] [Full Text]  

11C-JHU75528: A Radiotracer for PET Imaging of CB1 Cannabinoid Receptors
Andrew G. Horti, Hong Fan, Hiroto Kuwabara, John Hilton, Hayden T. Ravert, Daniel P. Holt, Mohab Alexander, Anil Kumar, Arman Rahmim, Ursula Scheffel, Dean F. Wong, and Robert F. Dannals
JNM 2006 47: 1689-1696. [Abstract] [Full Text]  

Synthesis and Biologic Evaluation of a Novel Serotonin 5-HT1A Receptor Radioligand, 18F-Labeled Mefway, in Rodents and Imaging by PET in a Nonhuman Primate
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JNM 2006 47: 1697-1706. [Abstract] [Full Text]  

Imaging of Tumor Angiogenesis Using 99mTc-Labeled Human Recombinant Anti-ED-B Fibronectin Antibody Fragments
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JNM 2006 47: 1707-1716. [Abstract] [Full Text]  

Evaluation of 4'-[Methyl-14C]Thiothymidine for In Vivo DNA Synthesis Imaging
Jun Toyohara, Katsutoshi Kumata, Kiyoshi Fukushi, Toshiaki Irie, and Kazutoshi Suzuki
JNM 2006 47: 1717-1722. [Abstract] [Full Text]  

131I Ablation Treatment in Young Females After the Chernobyl Accident
Curtis C. Travis and Michael G. Stabin
JNM 2006 47: 1723-1727. [Abstract] [Full Text]  




This Article
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