Journal of Nuclear Medicine Vol. 46 No. 8 8a-9a
© 2005 by Society of Nuclear Medicine
THIS MONTH IN JNM
Schöder and colleagues review approaches to interpretation of information from the CT portion of PET/CT imaging and preview 2 articles in this month’s JNM that indicate the independent benefits of CT in such procedures.
Page 1249
Bengel discusses the current status of cardiac neuroimaging and the implications of an article in this month’s JNM that provides new information on the relationship between myocardial ischemia and sympathetic nerve integrity.
Page 1252
Welch reviews current research on the potential benefits of 
-particles for specific tumor cell killing and previews an article in this month’s JNM that addresses key issues in creating 211At-labeled radiopharmaceuticals for therapeutic applications.
Page 1254
Schaefer and colleagues use cardiac MRI as a reference in evaluating the accuracy of the Emory Cardiac Tool Box in assessing left ventricular end-diastolic or end-systolic volumes and ejection fraction from gated 99mTc-MIBI SPECT.
Page 1256
El Fakhri and colleagues offer an analytic and modeling approach to solving 2 major challenges of 82Rb cardiac PET imaging––accurate noninvasive estimation of input function and absolute quantitation of myocardial perfusion.
Page 1264
Kaufmann and colleagues use PET imaging for in vivo validation of a novel Doppler-based method for calculating coronary volumetric blood flow and coronary flow reserve.
Page 1272
Dunphy and colleagues investigate the utility of PET/CT in examining the relationship of vascular calcification and vascular metabolic activity in the evolution of atheroma.
Page 1278
Giorgetti and colleagues compare 99mTc-tetrofosmin SPECT with contrast-enhanced MRI in the evaluation of myocardial fibrosis in patients with previous myocardial infarction and severe left ventricular dysfunction.
Page 1285
Hacker and colleagues report on a retrospective analysis contrasting the accuracies of multidetector angiography and myocardial perfusion imaging in the detection of hemodynamically relevant lesions of the coronary arteries.
Page 1294
Catafau and colleagues describe normal distribution, specific uptake values, variability, and reliability of the serotonin transporter SPECT ligand 123I-ADAM in healthy individuals.
Page 1301
Forrer and colleagues detail the results of a prospective study of 177Lu-DOTATOC treatment in patients with neuroendocrine tumors relapsed after 90Y-DOTATOC treatment.
Page 1310
Liu and colleagues compare 2 timing protocols for injection of furosemide and radiopharmaceuticals in diuretic renography.
Page 1317
van Westreenen and colleagues report on the rate and clinical relevance of unexpected synchronous primary neoplasms identified on 18F-FDG PET in staging of esophageal cancer.
Page 1321
Lambert and colleagues investigate the feasibility of intraarterial administration of 188Re-HDD/lipiodol as a treatment for hepatocellular carcinoma in patients with moderately advanced cirrhosis.
Page 1326
Beer and colleagues describe the kinetics and biodistribution of 18F-galacto-RGD as a PET tracer for quantification of vß3 expression in patients with metastases from melanomas and musculoskeletal sarcomas.
Page 1333
Nestle and colleagues compare gross tumor volumes resulting from 4 methods for definition of radiotherapy target volumes in patients with non–small cell lung cancer.
Page 1342
Bencherif and colleagues examine changes in binding potential of brain µ-opioid receptors as quantified in 11C-carfentanil PET imaging of individuals with bulimia nervosa.
Page 1349
Osman and colleagues assess the incremental added value and frequency of potentially clinically significant incidental findings from expert independent reading of the unenhanced-CT portion of PET/CT studies.
Page 1352
Even-Sapir reviews the basis for detection of malignant bone involvement with various morphologic and scintigraphic imaging modalities and the advantages and limitations of each.
Page 1356
Luisi and colleagues use 11C-hydroxyephedrine PET to investigate whether altered uptake of norepinephrine by sympathetic nerves in viable, dysfunctional myocardium can be imaged in vivo and to assess sympathetic dysinnervation in hibernating myocardium.
Page 1368
Richard and colleagues validate PET measurement of alveolar volume and regional ventilation assessment with inhaled 13N-N2 in a porcine model of acute lung injury.
Page 1375
de Vries and colleagues investigate radiolabeled dopamine D3 antagonist GR218231 as a PET tracer for monitoring P-glycoprotein activity in the blood–brain barrier, a technique with potential applications in drug development and identification of undesirable drug–drug interactions.
Page 1384
Pozzi and Zalutsky report on the effects of radiation dose on synthesis of N-succinimidyl 3-211At-astatobenzoate, a compound used in clinical trials for labeling antibodies with -particle–emitting 211At.
Page 1393
| ON THE COVER
Assessment of regional alveolar volume and ventilation is crucial to understanding the pathophysiology of lung injury. Measurement of 13N-N2 washout using PET has been shown to be accurate in assessing these parameters during experimental acute lung injury. This method can now systematically be used to investigate how the distribution of lung ventilation can be changed by interventions such as positive end-expiratory pressure, prone positioning, or recruitment maneuvers and how these changes may affect ventilator-induced lung injury.
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Related articles in JNM:
- CT in PET/CT: Essential Features of Interpretation
- Heiko Schöder, Henry W.D. Yeung, and Steven M. Larson
JNM 2005 46: 1249-1251.
[Full Text]
- When the Heart Loses Its Nerves...and How Nuclear Imaging Helps to Understand
- Frank M. Bengel
JNM 2005 46: 1252-1253.
[Full Text]
- Potential and Pitfalls of Therapy with -Particles
- Michael J. Welch
JNM 2005 46: 1254-1255.
[Full Text]
- Quantification of Left Ventricular Volumes and Ejection Fraction from Gated 99mTc-MIBI SPECT: MRI Validation and Comparison of the Emory Cardiac Tool Box with QGS and 4D-MSPECT
- Wolfgang M. Schaefer, Claudia S.A. Lipke, Dirk Standke, Harald P. Kühl, Bernd Nowak, Hans-Juergen Kaiser, Karl-Christian Koch, and Udalrich Buell
JNM 2005 46: 1256-1263.
[Abstract]
[Full Text]
- Quantitative Dynamic Cardiac 82Rb PET Using Generalized Factor and Compartment Analyses
- Georges El Fakhri, Arkadiusz Sitek, Bastien Guérin, Marie Foley Kijewski, Marcelo F. Di Carli, and Stephen C. Moore
JNM 2005 46: 1264-1271.
[Abstract]
[Full Text]
- Novel Doppler Assessment of Intracoronary Volumetric Flow Reserve: Validation Against PET in Patients With or Without Flow-Dependent Vasodilation
- Philipp A. Kaufmann, Mehdi Namdar, Felix Matthew, Marco Roffi, Schlomo V. Aschkenasy, Bernd van der Loo, Gabor Sutsch, Thomas F. Lüscher, and Rolf Jenni
JNM 2005 46: 1272-1277.
[Abstract]
[Full Text]
- Association of Vascular 18F-FDG Uptake with Vascular Calcification
- Mark P.S. Dunphy, Alvin Freiman, Steven M. Larson, and H. William Strauss
JNM 2005 46: 1278-1284.
[Abstract]
[Full Text]
- Baseline/Postnitrate Tetrofosmin SPECT for Myocardial Viability Assessment in Patients with Postischemic Severe Left Ventricular Dysfunction: New Evidence from MRI
- Assuero Giorgetti, Alessandro Pingitore, Brunella Favilli, Annette Kusch, Massimo Lombardi, and Paolo Marzullo
JNM 2005 46: 1285-1293.
[Abstract]
[Full Text]
- Comparison of Spiral Multidetector CT Angiography and Myocardial Perfusion Imaging in the Noninvasive Detection of Functionally Relevant Coronary Artery Lesions: First Clinical Experiences
- Marcus Hacker, Tobias Jakobs, Florian Matthiesen, Christian Vollmar, Konstantin Nikolaou, Christoph Becker, Andreas Knez, Thomas Pfluger, Maximilian Reiser, Klaus Hahn, and Reinhold Tiling
JNM 2005 46: 1294-1300.
[Abstract]
[Full Text]
- SPECT of Serotonin Transporters Using 123I-ADAM: Optimal Imaging Time After Bolus Injection and Long-Term Test–Retest in Healthy Volunteers
- Ana M. Catafau, Víctor Pérez, María M. Penengo, Santiago Bullich, Mónica Danús, Dolors Puigdemont, Juan C. Pascual, Iluminada Corripio, Jordi Llop, Javier Perich, and Enric Álvarez
JNM 2005 46: 1301-1309.
[Abstract]
[Full Text]
- Treatment with 177Lu-DOTATOC of Patients with Relapse of Neuroendocrine Tumors After Treatment with 90Y-DOTATOC
- Flavio Forrer, Helena Uusijärvi, Daniel Storch, Helmut R. Maecke, and Jan Mueller-Brand
JNM 2005 46: 1310-1316.
[Abstract]
[Full Text]
- The F+0 Protocol for Diuretic Renography Results in Fewer Interrupted Studies Due to Voiding Than the F-15 Protocol
- Yiyan Liu, Nasrin V. Ghesani, Joan H. Skurnick, and Lionel S. Zuckier
JNM 2005 46: 1317-1320.
[Abstract]
[Full Text]
- Synchronous Primary Neoplasms Detected on 18F-FDG PET in Staging of Patients with Esophageal Cancer
- Henderik L. van Westreenen, Marinke Westerterp, Pieter L. Jager, Hendrik M. van Dullemen, Gerrit W. Sloof, Emile F.I. Comans, J. Jan B. van Lanschot, Theo Wiggers, and John Th.M. Plukker
JNM 2005 46: 1321-1325.
[Abstract]
[Full Text]
- 188Re-HDD/Lipiodol for Treatment of Hepatocellular Carcinoma: A Feasibility Study in Patients with Advanced Cirrhosis
- Bieke Lambert, Klaus Bacher, Katrien De Keukeleire, Peter Smeets, Isabelle Colle, Jae Min Jeong, Hubert Thierens, Roberto Troisi, Filip De Vos, and Christophe Van de Wiele
JNM 2005 46: 1326-1332.
[Abstract]
[Full Text]
- Biodistribution and Pharmacokinetics of the vß3-Selective Tracer 18F-Galacto-RGD in Cancer Patients
- Ambros J. Beer, Roland Haubner, Michael Goebel, Stephan Luderschmidt, Mary E. Spilker, Hans-Jürgen Wester, Wolfgang A. Weber, and Markus Schwaiger
JNM 2005 46: 1333-1341.
[Abstract]
[Full Text]
- Comparison of Different Methods for Delineation of 18F-FDG PET–Positive Tissue for Target Volume Definition in Radiotherapy of Patients with Non–Small Cell Lung Cancer
- Ursula Nestle, Stephanie Kremp, Andrea Schaefer-Schuler, Christiane Sebastian-Welsch, Dirk Hellwig, Christian Rübe, and Carl-Martin Kirsch
JNM 2005 46: 1342-1348.
[Abstract]
[Full Text]
- Regional µ-Opioid Receptor Binding in Insular Cortex Is Decreased in Bulimia Nervosa and Correlates Inversely with Fasting Behavior
- Badreddine Bencherif, Angela S. Guarda, Carlo Colantuoni, Hayden T. Ravert, Robert F. Dannals, and J. James Frost
JNM 2005 46: 1349-1351.
[Abstract]
[Full Text]
- Clinically Significant Incidental Findings on the Unenhanced CT Portion of PET/CT Studies: Frequency in 250 Patients
- Medhat M. Osman, Christian Cohade, Elliot K. Fishman, and Richard L. Wahl
JNM 2005 46: 1352-1355.
[Abstract]
[Full Text]
- Imaging of Malignant Bone Involvement by Morphologic, Scintigraphic, and Hybrid Modalities
- Einat Even-Sapir
JNM 2005 46: 1356-1367.
[Abstract]
[Full Text]
- Regional 11C-Hydroxyephedrine Retention in Hibernating Myocardium: Chronic Inhomogeneity of Sympathetic Innervation in the Absence of Infarction
- Andrew J. Luisi, Jr., Gen Suzuki, Robert deKemp, Michael S. Haka, Steven A. Toorongian, John M. Canty, Jr., and James A. Fallavollita
JNM 2005 46: 1368-1374.
[Abstract]
[Full Text]
- Quantitative Assessment of Regional Alveolar Ventilation and Gas Volume Using 13N-N2 Washout and PET
- Jean-Christophe Richard, Marc Janier, Franck Lavenne, Christian Tourvieille, Didier Le Bars, Nicolas Costes, Gerard Gimenez, and Claude Guerin
JNM 2005 46: 1375-1383.
[Abstract]
[Full Text]
- Synthesis and Evaluation of Dopamine D3 Receptor Antagonist 11C-GR218231 as PET Tracer for P-Glycoprotein
- Erik F.J. de Vries, Rudie Kortekaas, Aren van Waarde, Durk Dijkstra, Philip H. Elsinga, and Willem Vaalburg
JNM 2005 46: 1384-1392.
[Abstract]
[Full Text]
- Radiopharmaceutical Chemistry of Targeted Radiotherapeutics, Part 2: Radiolytic Effects of 211At -Particles Influence N-Succinimidyl 3-211At-Astatobenzoate Synthesis
- Oscar R. Pozzi and Michael R. Zalutsky
JNM 2005 46: 1393-1400.
[Abstract]
[Full Text]
