Journal of Nuclear Medicine Vol. 46 No. 5 8a-9a
© 2005 by Society of Nuclear Medicine
THIS MONTH IN JNM
Tulchinsky and Peters outline the development of leukocyte receptor-binding radiotracers and describe requirements for ideal infection and inflammation imaging agents.
Page 718
Sciagrà and colleagues report on the use of gated SPECT to assess the effect of abciximab therapy on outcomes after myocardial reperfusion in patients with acute myocardial infarction.
Page 722
Slomka and colleagues apply delayed-enhancement MRI as a validation tool to measure the accuracy of a novel automated myocardial perfusion 201Tl SPECT quantification method, based on normal limits, for detection and sizing of infarcts.
Page 728
Fricke and colleagues evaluate the enhanced accuracy of a SPECT/low-dose CT device in myocardial perfusion scintigraphy and compare results with those from 13N-ammonia PET.
Page 736
van Dyck and colleagues use 123I-ß-CIT to investigate the relationship between striatal dopamine transporter (DAT) protein availability and a polymorphism of the gene that codes for DAT and discuss the implications of their findings for neuropsychiatric studies.
Page 745
Ishimori and colleagues report on the detection of unexpected 18F-FDG-avid additional primary malignant tumors, as well as false-positive results, in patients being evaluated by whole-body 18F-FDG PET/CT for known or suspected malignancies.
Page 752
Israel and colleagues study the nature and significance of unexpected focal 18F-FDG uptake localized by PET/CT within the gastrointestinal tract in a retrospective review of more than 4,000 patients.
Page 758
Henze and colleagues describe the pharmacokinetic modeling of the high uptake of 68Ga-DOTA-TOC in meningiomas and offer data that may serve as a basis for the use of PET in radiotherapy planning and subsequent monitoring of somatostatin receptors.
Page 763
Yen and colleagues evaluate the sensitivity and prognostic significance of whole-body 18F-FDG PET for follow-up evaluation of recurrences and metastases in patients with nasopharyngeal carcinoma.
Page 770
Yen and colleagues detail a study evaluating the utility of PET in staging untreated squamous cell carcinoma of the buccal mucosa and compare the results with those from CT and MRI and histopathology.
Page 775
Zitzmann and colleagues report on a novel bacterial peptide display system as an alternative to phage peptide display for the isolation of new prostate tumor-specific peptides.
Page 782
van Eerd and colleagues study the pharmacodynamics of 111In-DPC11870 to determine the mechanism of accumulation of the radiolabeled LTB4 antagonist in infectious and inflammatory foci in an animal model.
Page 786
Takei and colleagues elucidate the relationship between apoptosis and glucose utilization during cancer chemotherapy using 99mTc-annexin V and 18F-FDG and compare the uptake of these tracers in a rat tumor model.
Page 794
Semnani and colleagues assess the efficacy of targeting of lung metastases in mice with various formulations of the radioiodinated thymidine analog 123I-IUdR/125I-IUdR.
Page 800
Tait and colleagues look at ways in which changes in membrane-binding affinity, molecular charge, and method of labeling affect the biodistribution of 99mTc-annexin V in normal and apoptotic tissues.
Page 807
Zhou and colleagues describe the potential of dual-tracer small-animal SPECT in simultaneous imaging of 99mTc-sestamibi to assess myocardial perfusion and of 111In-labeled stem cells to delineate stem cell grafts in regions of infarct.
Page 816
Maina and colleagues compare the biologic profiles of 99mTc-demobesin 1 and 111In-Z-070 using various gastrin-releasing peptide receptor (GRP-R)-expressing tissues of human and animal origin and discuss the implications for the development of bombesin analogs for GRP-R-targeting applications.
Page 823
Altmann and colleagues visualize functional protein-to-protein interaction as thyroid transcription factors induce reporter gene expression in rat hepatoma cells and report on the ability of these factors to induce endogenous thyroid-specific gene expression and iodide accumulation in nonthyroid tumor cells.
Page 831
Dewaraja and colleagues describe the accuracy of 131I activity quantification and absorbed dose estimation when patient-specific, 3-dimensional methods are used for SPECT reconstruction and absorbed dose calculation and discuss the implications for advances in radioimmunotherapy.
Page 840
Vallabhajosula and colleagues evaluate the potential value of several factors in predicting myelotoxicity associated with 90Y- and 131I-labeled monoclonal antibody therapy in patients with prostate cancer.
Page 850
Brasse and colleagues use 3-dimensional whole-body PET simulations and phantom studies to investigate how gains in noise equivalent count rates from a noiseless random coincidence estimation method are translated to improvements in signal-to-noise ratio, with accompanying potential for reduction in scan duration.
Page 859
Seo and colleagues evaluate an iterative reconstruction algorithm using SPECT/CT data from phantoms and 111In-capromab pendetide studies to assess the utility of a commercial SPECT/CT system in imaging of postprostatectomy patients at risk for residual or recurrent disease.
Page 868
Cheng and colleagues describe the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry as a potential tool for high-throughput screening and characterization of molecular imaging probes or drug design and development.
Page 878
Froidevaux and colleagues evaluate the receptor-binding potency and biodistribution of radiolabeled analogs of 
-melanocyte-stimulating hormone in a mouse melanoma model.
Page 887
| ON THE COVER
In patients with known cancer, work-ups often focus on the primary disease, and incidental coexistence of another primary malignant lesion can be missed. The prevalence of additional primary neoplasms is substantial. Whole-body PET with 18F-FDG has been used successfully and with increasing frequency in the evaluation and clinical management of an expanding number of neoplasms. Reports also indicate that 18F-FDG PET has the potential for cancer screening and can detect new malignant tumors in a small fraction of asymptomatic individuals. Because PET/CT allows precise determination of the location of 18F-FDG uptake, whole-body studies may be of value in the detection of unexpected additional primary malignant tumors in patients with known or suspected malignancies.
|
Related articles in JNM:
- Leukocyte Receptor-Binding Radiopharmaceuticals for Infection and Inflammation Scintigraphy
- Mark Tulchinsky and A. Michael Peters
JNM 2005 46: 718-721.
[Full Text]
- Gated SPECT Evaluation of Outcome After Abciximab-Supported Primary Infarct Artery Stenting for Acute Myocardial Infarction: The Scintigraphic Data of the Abciximab and Carbostent Evaluation (ACE) Randomized Trial
- Roberto Sciagrà, Guido Parodi, Alberto Pupi, Angela Migliorini, Renato Valenti, Guia Moschi, Giovanni Maria Santoro, Gentian Memisha, and David Antoniucci
JNM 2005 46: 722-727.
[Abstract]
[Full Text]
- Automatic Detection and Size Quantification of Infarcts by Myocardial Perfusion SPECT: Clinical Validation by Delayed-Enhancement MRI
- Piotr J. Slomka, David Fieno, Louise Thomson, John D. Friedman, Sean W. Hayes, Guido Germano, and Daniel S. Berman
JNM 2005 46: 728-735.
[Abstract]
[Full Text]
- Attenuation Correction of Myocardial SPECT Perfusion Images with Low-Dose CT: Evaluation of the Method by Comparison with Perfusion PET
- Eva Fricke, Harald Fricke, Reiner Weise, Annett Kammeier, Ralph Hagedorn, Norbert Lotz, Oliver Lindner, Diethelm Tschoepe, and Wolfgang Burchert
JNM 2005 46: 736-744.
[Abstract]
[Full Text]
- Increased Dopamine Transporter Availability Associated with the 9-Repeat Allele of the SLC6A3 Gene
- Christopher H. van Dyck, Robert T. Malison, Leslie K. Jacobsen, John P. Seibyl, Julie K. Staley, Marc Laruelle, Ronald M. Baldwin, Robert B. Innis, and Joel Gelernter
JNM 2005 46: 745-751.
[Abstract]
[Full Text]
- Detection of Unexpected Additional Primary Malignancies with PET/CT
- Takayoshi Ishimori, Pavni V. Patel, and Richard L. Wahl
JNM 2005 46: 752-757.
[Abstract]
[Full Text]
- PET/CT Detection of Unexpected Gastrointestinal Foci of 18F-FDG Uptake: Incidence, Localization Patterns, and Clinical Significance
- Ora Israel, Nikolay Yefremov, Rachel Bar-Shalom, Olga Kagana, Alex Frenkel, Zohar Keidar, and Doron Fischer
JNM 2005 46: 758-762.
[Abstract]
[Full Text]
- Characterization of 68Ga-DOTA-D-Phe1-Tyr3-Octreotide Kinetics in Patients with Meningiomas
- Marcus Henze, Antonia Dimitrakopoulou-Strauss, Stefanie Milker-Zabel, Jochen Schuhmacher, Ludwig G. Strauss, Josef Doll, Helmut R. Mäcke, Michael Eisenhut, Jürgen Debus, and Uwe Haberkorn
JNM 2005 46: 763-769.
[Abstract]
[Full Text]
- Whole-Body 18F-FDG PET in Recurrent or Metastatic Nasopharyngeal Carcinoma
- Ruoh-Fang Yen, Ruey-Long Hong, Kai-Yuan Tzen, Mei-Hsiu Pan, and Tony Hsiu-Hsi Chen
JNM 2005 46: 770-774.
[Abstract]
[Full Text]
- Staging of Untreated Squamous Cell Carcinoma of Buccal Mucosa with 18F-FDG PET: Comparison with Head and Neck CT/MRI and Histopathology
- Tzu-Chen Yen, Joseph Tung-Chieh Chang, Shu-Hang Ng, Yu-Chen Chang, Sheng-Chieh Chan, Hung-Ming Wang, Lai-Chu See, Tsung-Ming Chen, Chung-Jan Kang, Yi-Fen Wu, Kun-Ju Lin, and Chun-Ta Liao
JNM 2005 46: 775-781.
[Abstract]
[Full Text]
- Identification of a New Prostate-Specific Cyclic Peptide with the Bacterial FliTrx System
- Sabine Zitzmann, Susanne Krämer, Walter Mier, Miriam Mahmut, Julian Fleig, Annette Altmann, Michael Eisenhut, and Uwe Haberkorn
JNM 2005 46: 782-785.
[Abstract]
[Full Text]
- Scintigraphic Imaging of Infectious Foci with an 111In-LTB4 Antagonist Is Based on In Vivo Labeling of Granulocytes
- Julliëtte E.M. van Eerd, Wim J.G. Oyen, Thomas D. Harris, Huub J.J.M. Rennen, D. Scott Edwards, Frans H.M. Corstens, and Otto C. Boerman
JNM 2005 46: 786-793.
[Abstract]
[Full Text]
- Enhanced Apoptotic Reaction Correlates with Suppressed Tumor Glucose Utilization After Cytotoxic Chemotherapy: Use of 99mTc-Annexin V, 18F-FDG, and Histologic Evaluation
- Toshiki Takei, Yuji Kuge, Songji Zhao, Masayuki Sato, H. William Strauss, Francis G. Blankenberg, Jonathan F. Tait, and Nagara Tamaki
JNM 2005 46: 794-799.
[Abstract]
[Full Text]
- 5-[123I/125I]Iodo-2'-Deoxyuridine in Metastatic Lung Cancer: Radiopharmaceutical Formulation Affects Targeting
- Elham Safaie Semnani, Ketai Wang, S. James Adelstein, and Amin I. Kassis
JNM 2005 46: 800-806.
[Abstract]
[Full Text]
- Structural Requirements for In Vivo Detection of Cell Death with 99mTc-Annexin V
- Jonathan F. Tait, Christina Smith, and Francis G. Blankenberg
JNM 2005 46: 807-815.
[Abstract]
[Full Text]
- In Vivo Detection of Stem Cells Grafted in Infarcted Rat Myocardium
- Rong Zhou, Daniel H. Thomas, Hui Qiao, Harshali S. Bal, Seok-Rye Choi, Abass Alavi, Victor A. Ferrari, Hank F. Kung, and Paul D. Acton
JNM 2005 46: 816-822.
[Abstract]
[Full Text]
- Species Differences of Bombesin Analog Interactions with GRP-R Define the Choice of Animal Models in the Development of GRP-R–Targeting Drugs
- Theodosia Maina, Berthold A. Nock, Hanwen Zhang, Anastasia Nikolopoulou, Beatrice Waser, Jean-Claude Reubi, and Helmut R. Maecke
JNM 2005 46: 823-830.
[Abstract]
[Full Text]
- Effects of Pax8 and TTF-1 Thyroid Transcription Factor Gene Transfer in Hepatoma Cells: Imaging of Functional Protein–Protein Interaction and Iodide Uptake
- Annette Altmann, Ralf B. Schulz, Gabriela Glensch, Helmut Eskerski, Sabine Zitzmann, Michael Eisenhut, and Uwe Haberkorn
JNM 2005 46: 831-839.
[Abstract]
[Full Text]
- Accurate Dosimetry in 131I Radionuclide Therapy Using Patient-Specific, 3-Dimensional Methods for SPECT Reconstruction and Absorbed Dose Calculation
- Yuni K. Dewaraja, Scott J. Wilderman, Michael Ljungberg, Kenneth F. Koral, Kenneth Zasadny, and Mark S. Kaminiski
JNM 2005 46: 840-849.
[Abstract]
[Full Text]
- Prediction of Myelotoxicity Based on Bone Marrow Radiation-Absorbed Dose: Radioimmunotherapy Studies Using 90Y- and 177Lu-Labeled J591 Antibodies Specific for Prostate-Specific Membrane Antigen
- Shankar Vallabhajosula, Stanley J. Goldsmith, Klaus A. Hamacher, Lale Kostakoglu, Shota Konishi, Mathew I. Milowski, David M. Nanus, and Neil H. Bander
JNM 2005 46: 850-858.
[Abstract]
[Full Text]
- Correction Methods for Random Coincidences in Fully 3D Whole-Body PET: Impact on Data and Image Quality
- David Brasse, Paul E. Kinahan, Carole Lartizien, Claude Comtat, Mike Casey, and Christian Michel
JNM 2005 46: 859-867.
[Abstract]
[Full Text]
- Correction of Photon Attenuation and Collimator Response for a Body-Contouring SPECT/CT Imaging System
- Youngho Seo, Kenneth H. Wong, Mingshan Sun, Benjamin L. Franc, Randall A. Hawkins, and Bruce H. Hasegawa
JNM 2005 46: 868-877.
[Abstract]
[Full Text]
- A New Strategy to Screen Molecular Imaging Probe Uptake in Cell Culture Without Radiolabeling Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
- Zhen Cheng, Richard C. Winant, and Sanjiv S. Gambhir
JNM 2005 46: 878-886.
[Abstract]
[Full Text]
- Melanoma Targeting with DOTA--Melanocyte-Stimulating Hormone Analogs: Structural Parameters Affecting Tumor Uptake and Kidney Uptake
- Sylvie Froidevaux, Martine Calame-Christe, Heidi Tanner, and Alex N. Eberle
JNM 2005 46: 887-895.
[Abstract]
[Full Text]
