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FIGURE 2. Striatal DAT availability (V₃'') vs. age (in years) as measured by ¹²³I-ß-CIT SPECT in 94 healthy European Americans grouped according to SLC6A3 VNTR genotype. SLC6A3_*9R carriers (n = 41) had significantly higher striatal DAT availability (V₃'') than did SLC6A3_*10R homozygotes (n = 53), controlling for age (F_1,93 = 6.25, P = 0.014, ANCOVA). Both genotypic subgroups showed similar aging effects: For _*9R carriers, V₃'' declined by 44% over age range 18–88 y, or approximately 6.3% per decade. For _*10R homozygotes, V₃'' declined by 43% over age range 18–88 y, or approximately 6.2% per decade.

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