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FIGURE 1. Treatment plan. Each patient received a pretherapy imaging study with 111In-hMN-14 IgG. This study was used to (a) confirm targeting of at least 1 index lesion, (b) estimate radiation-absorbed doses for 90Y-hMN-14 to ensure that the dose to liver would not exceed 3,000 cGy and the lung and kidney dose would not exceed 2,000 cGy at prescribed 90Y-hMN-14 administered dose, and (c) to verify that amount of 90Y radioactivity remaining in the whole body would be
3 mCi/m2 no later than 14 d in order to reinfuse PBSCs within this time. PBSCs were reinfused between 7 and 12 d, depending on dose level. G-CSF = granulocyte colony-stimulating factor; Mab = monoclonal antibody