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FIGURE 1. ROC curves for detection of recurrent CRC by PET, in-line PET/CT, and software fusion of PET and CT in region-based analysis. Analysis was based on 143 evaluable regions in a total study population of 51 patients. According to the reference standard, 35 regions were positive and 108 regions were negative for tumor tissue. Area under the curve is 0.82 for PET and 0.95 for in-line PET/CT (P = 0.01). TPR = true-positive rate; FPR = false-positive rate.