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FIGURE 2. Patient with diffuse HI (patient 12). (A) Larger and diffuse uptake of radiotracer is observed over pancreatic area (P) (coronal and axial projections). Physiologic distribution of radiotracer with higher accumulation in kidneys (K) and urinary bladder (UB) and lower accumulation in liver (L) is also observed. (B) Images obtained for same patient after carbidopa administration: Note absence of 18F-fluoro-L-DOPA uptake by pancreas. (C) Corresponding immunohistochemical results (proinsulin, snaptophysin, chromogranin A, and AADC) obtained for same patient after subtotal pancreatectomy (x100).
