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FIGURE 5. Relative suppression of WBC counts as function of absorbed dose to bone marrow in nude mice when injected with ²¹¹At-conjugated ( ${blacktriangleup}$ , n = 38) and ^99mTc-conjugated ( ${blacksquare}$ , n = 20) mAbs or when irradiated externally with a ⁶⁰Co source ( ${square}$ , n = 19). The y-axis is logarithmic, where 1 represents no suppression and 0.1 represents 90% suppression of WBC counts. Solid lines represent exponential fits to ²¹¹At and ^99mTc data. Dashed lines flanking each full line represent 95% confidence interval. In vivo RBE is defined as quotient of absorbed dose from ^99mTc and that from ²¹¹At for equal toxic effect—that is, for equal degrees of suppression of WBC counts. The 2 data points with error bars originate from preliminary experiments with ^99mTc-88BV59, where cumulated blood activity concentrations and suppression of WBC counts were investigated in separate animals ( ${blacksquare}$ , n = 10).

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