Click on image to view larger version.
FIGURE 2. WBC counts, RBC counts, PLT counts, and HGB as function of time after injection during the long-term study, when animals were injected intraperitoneally with 211At-conjugated (
) and 99mTc-conjugated (
) mAb 88BV59 (n = 17 and 30, respectively), giving an absorbed dose to bone marrow of approximately 0.3 and 1.3 Gy, respectively. The nadir of WBC counts was reached at days 4–7. Results from control animals (unlabeled antibody 88BV59 [n = 20] and PBS [n = 30]) are also plotted (•). Since no significant (P > 0.05) difference between unlabeled antibody and PBS was observed, the 2 control groups were put together. Day 5 was chosen as the reference point when comparing myelotoxicity of different combinations of nuclide and antibody (Fig. 5). Values are means ± SEM.
