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FIGURE 4. Human PET study. (A) Coregistered planes of contrast agentenhanced MR image (left) and 18F-CPFPX PET image (right) of recurrent glioblastoma multiforme in right temporal region. Circular zone (white arrowheads) in MR image indicates top of solid tumor and surrounding tissue. (B) Circular accumulation (boxed area) of 18F-CPFPX (right) corresponding to contrast agentenhanced region in MR image (left). (C) High magnification of B. Adjacent to circular peritumoral ligand accumulation, a zone of gray matter, most likely temporal cortex, has been compressed and displaced by tumor (arrowheads).