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FIGURE 2. Blood sampling for FLT was acquired through either venous or arterial catheters at various times after injection. (A) Several patients (n = 6) had both blood and plasma activity determined from each sample. (B) Activity in blood after injection of 18F-FLT is comprised of both FLT and a labeled metabolite (FLT-glucuronide) determined by an independent assay. (C) Combining total activity in blood and the FLT fraction permits generation of an input function for FLT used to quantitate FLT tissue retention. %ID/g = percentage injected dose per gram.
