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FIGURE 1. Kinetic model of FLT metabolism is comprised of an exchangeable tissue compartment and a compartment of trapped FLT phosphate nucleotides. Four rate constants describe kinetic transfer rates between the 2 compartments. FLTMP = FLT-monophosphate; FLTDP = FLT-diphosphate; FLTTP = FLT-triphosphate; FLT-gluc = FLT-glucuronide; Qe = exchangeable tissue compartment; Qm = compartment of trapped FLT phosphorylated nucleotides; CpFLT = concentration of FLT in arterial plasma; Cmet = concentration of metabolites in arterial plasma.
